From: Race and BMI modify associations of calcium and vitamin D intake with prostate cancer
 | Controls |  | Cases vs. Controls |  | NCCN High Risk vs. Controls |  | Gleason Score ≥4 + 3 vs. Controls | |||
---|---|---|---|---|---|---|---|---|---|---|
Unadjusted | Adjusted | Unadjusted | Adjusted | Unadjusted | Adjusted | |||||
 | n (%) | n (%) | OR (95% C.I.) | OR (95% C.I.) | n (%) | OR (95% C.I.) | OR (95% C.I.) | n (%) | OR (95% C.I.) | OR (95% C.I.) |
Dietary Calcium, mg/day | ||||||||||
 Quartile 1 (<283.5) | 236 (24.6) | 178 (25.5) | 1.00 | 1.00 | 35 (22.3) | 1.00 | 1.00 | 30 (19.4) | 1.00 | 1.00 |
 Quartile 2 (283.5–504.4) | 246 (25.7) | 168 (24.0) | 0.91 (0.69–1.19) | 0.86 (0.63–1.18) | 32 (20.4) | 0.88 (0.53–1.46) | 0.88 (0.48–1.61) | 33 (21.3) | 1.06 (0.62–1.79) | 0.99 (0.55–1.79) |
 Quartile 3 (504.5–813.1) | 247 (25.8) | 168 (24.0) | 0.90 (0.68–1.19) | 0.93 (0.67–1.30) | 35 (22.3) | 0.96 (0.58–1.58) | 1.37 (0.73–2.57) | 38 (24.5) | 1.21 (0.73–2.02) | 1.47 (0.82–2.66) |
 Quartile 4 (>813.1) | 229 (23.9) | 185 (26.5) | 1.07 (0.81–1.41) | 0.98 (0.69–1.39) | 55 (35.0) | 1.62 (1.02–2.57) | 1.43 (0.76–2.71) | 54 (34.8) | 1.86 (1.15–3.00) | 1.80 (1.00–3.25) |
 P for Trend |  |  | 0.49 | 0.92 |  | 0.04 | 0.07 |  | 0.03 | 0.02 |
Dietary Vitamin D, IU/day | ||||||||||
 Quartile 1 (<29.9) | 249 (26.0) | 165 (23.6) | 1.00 | 1.00 | 26 (16.6) | 1.00 | 1.00 | 29 (18.7) | 1.00 | 1.00 |
 Quartile 2 (29.9–71.4) | 244 (25.5) | 170 (24.3) | 1.05 (0.80–1.39) | 0.98 (0.71–1.35) | 41 (26.1) | 1.61 (0.96–2.71) | 1.24 (0.68–2.29) | 37 (23.9) | 1.30 (0.77–2.18) | 1.03 (0.58–1.84) |
 Quartile 3 (71.5–148.3) | 229 (23.9) | 186 (26.6) | 1.23 (0.93–1.62) | 1.15 (0.81–1.63) | 48 (30.6) | 2.01 (1.21–3.34) | 1.45 (0.75–2.80) | 46 (29.7) | 1.73 (1.05–2.84) | 1.28 (0.69–2.37) |
 Quartile 4 (>148.3) | 236 (24.6) | 178 (25.5) | 1.14 (0.86–1.50) | 1.01 (0.67–1.50) | 42 (26.8) | 1.70 (1.01–2.86) | 0.86 (0.40–1.86) | 43 (27.7) | 1.56 (0.95–2.59) | 0.96 (0.48–1.93) |
 P for Trend |  |  | 0.35 | 0.87 |  | 0.13 | 0.38 |  | 0.11 | 0.93 |
Supplemental Calcium, mg/day | ||||||||||
 0 | 464 (48.4) | 384 (54.9) | 1.00 | 1.00 | 94 (59.9) | 1.00 | 1.00 | 83 (53.5) | 1.00 | 1.00 |
 0–400 | 103 (10.8) | 41 (5.9) | 0.48 (0.33–0.71) | 0.66 (0.2–1.03) | 8 (5.1) | 0.38 (0.18–0.81) | 0.67 (0.28–1.59) | 11 (7.1) | 0.60 (0.31–1.16) | 1.02 (0.48–2.14) |
 ≥400 | 391 (40.8) | 274 (39.2) | 0.85 (0.69–1.04) | 0.88 (0.69–1.13) | 55 (35.0) | 0.69 (0.49–0.99) | 0.64 (0.40–1.01) | 61 (39.4) | 0.87 (0.61–1.25) | 0.79 (0.52–1.22) |
 P for Trend |  |  | 0.20 | 0.39 |  | 0.07 | 0.05 |  | 0.54 | 0.29 |
Total Calcium, mg/day | ||||||||||
 Quartile 1 (<368.8) | 240 (25.1) | 174 (24.9) | 1.00 | 1.00 | 34 (21.7) | 1.00 | 1.00 | 30 (19.4) | 1.00 | 1.00 |
 Quartile 2 (368.8–616.0) | 249 (26.0) | 165 (23.6) | 0.91 (0.69–1.21) | 0.94 (0.67–1.31) | 34 (21.7) | 0.96 (0.58–1.60) | 1.10 (0.59–2.02) | 34 (21.9) | 1.09 (0.65–1.84) | 1.12 (0.62–2.05) |
 Quartile 3 (616.1–1033.3) | 234 (24.4) | 181 (25.9) | 1.07 (0.81–1.41) | 1.19 (0.84–1.68) | 38 (24.2) | 1.15 (0.70–1.88) | 1.38 (0.72–2.63) | 43 (27.7) | 1.47 (0.89–2.42) | 1.66 (0.91–3.04) |
 Quartile 4 (>1033.3) | 235 (24.5) | 179 (25.6) | 1.05 (0.80–1.38) | 1.06 (0.74–1.53) | 51 (32.5) | 1.53 (0.96–2.45) | 1.98 (1.01–3.91) | 48 (31.0) | 1.63 (1.01–2.67) | 1.83 (0.97–3.48) |
 P for Trend |  |  | 0.49 | 0.68 |  | 0.04 | 0.03 |  | 0.03 | 0.03 |
Total Vitamin D, IU/day | ||||||||||
 Quartile 1 (<63.5) | 231 (24.1) | 183 (26.2) | 1.00 | 1.00 | 39 (24.8) | 1.00 | 1.00 | 36 (23.2) | 1.00 | 1.00 |
 Quartile 2 (63.5–239.2) | 244 (25.5) | 170 (24.3) | 0.88 (0.67–1.16) | 0.86 (0.61–1.21) | 39 (24.8) | 0.95 (0.58–1.53) | 0.85 (0.46–1.56) | 38 (24.5) | 1.00 (0.61–1.63) | 0.91 (0.50–1.65) |
 Quartile 3 (239.3–510.2) | 239 (24.9) | 176 (25.2) | 0.93 (0.71–1.22) | 0.89 (0.63–1.25) | 52 (33.1) | 1.29 (0.82–2.03) | 1.03 (0.57–1.89) | 46 (29.7) | 1.24 (0.77–1.98) | 1.08 (0.60–1.93) |
 Quartile 4 (>510.2) | 244 (25.5) | 170 (24.3) | 0.88 (0.67–1.16) | 0.81 (0.56–1.16) | 27 (17.2) | 0.66 (0.39–1.11) | 0.38 (0.18–0.79) | 35 (22.6) | 0.92 (0.56–1.52) | 0.64 (0.33–1.23) |
 P for Trend |  |  | 0.55 | 0.39 |  | 0.17 | 0.01 |  | 0.80 | 0.16 |