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Table 4 Univariate and multivariate analyses of factors associated with survival and recurrence in BCLC stage A patients (n = 1192)

From: Microvascular invasion has limited clinical values in hepatocellular carcinoma patients at Barcelona Clinic Liver Cancer (BCLC) stages 0 or B

Features Overall survival Recurrence-free survival
Univariate P Multivariate Univariate P Multivariate
HR 95% CI P HR 95% CI P
Age, ≤52 vs. >52 year 0.751    NA 0.871    NA
Gender, female vs. male 0.434    NA 0.673    NA
Hepatitis B history, yes vs. no 0.025    NS 0.023    NS
Liver cirrhosis, yes vs. no 0.007 1.564 1.181–2.071 0.002 0.030 1.401 1.093–1.796 0.008
α-Fetoprotein, >200 vs. ≤200 ng/dL <0.001 1.644 1.354–1.996 <0.001 <0.001 1.468 1.227–1.758 <0.001
ALT, >75 vs. ≤75 U/L 0.745    NS 0.494    NA
γ-GT, >50 vs. ≤50 U/L <0.001 1.327 1.074–1.640 0.009 <0.001 1.246 1.030–1.509 0.024
Albumin, >35 vs. ≤35 g/L 0.001    NS 0.009    NS
Tumor size, >5 vs. ≤5 cm <0.001 2.080 1.698–2.548 <0.001 <0.001 1.847 1.533–2.225 <0.001
Tumor number, solitary vs. multiple 0.837    NA 0.505    NA
Tumor differentiation, III–IV vs. I–II <0.001 1.272 1.038–1.559 0.020 <0.001 1.250 1.033–1.514 0.022
Tumor encapsulation, complete vs. none <0.001 1.279 1.056–1.549 0.012 0.001 1.225 1.026–1.463 0.025
Microvascular invasion, yes vs. no <0.001 1.431 1.163–1.761 0.001 <0.001 1.400 1.150–1.705 0.001