Table 4 Univariate and multivariate analyses of factors associated with survival and recurrence in BCLC stage A patients (n = 1192)

Age, ≤52 vs. >52 year

0.751

NA

0.871

NA

Gender, female vs. male

0.434

NA

0.673

NA

Hepatitis B history, yes vs. no

0.025

NS

0.023

NS

Liver cirrhosis, yes vs. no

0.007

1.564

1.181–2.071

0.002

0.030

1.401

1.093–1.796

0.008

α-Fetoprotein, >200 vs. ≤200 ng/dL

<0.001

1.644

1.354–1.996

<0.001

<0.001

1.468

1.227–1.758

<0.001

ALT, >75 vs. ≤75 U/L

0.745

NS

0.494

NA

γ-GT, >50 vs. ≤50 U/L

<0.001

1.327

1.074–1.640

0.009

<0.001

1.246

1.030–1.509

0.024

Albumin, >35 vs. ≤35 g/L

0.001

NS

0.009

NS

Tumor size, >5 vs. ≤5 cm

<0.001

2.080

1.698–2.548

<0.001

<0.001

1.847

1.533–2.225

<0.001

Tumor number, solitary vs. multiple

0.837

NA

0.505

NA

Tumor differentiation, III–IV vs. I–II

<0.001

1.272

1.038–1.559

0.020

<0.001

1.250

1.033–1.514

0.022

Tumor encapsulation, complete vs. none

<0.001

1.279

1.056–1.549

0.012

0.001

1.225

1.026–1.463

0.025

Microvascular invasion, yes vs. no

<0.001

1.431

1.163–1.761

0.001

<0.001

1.400

1.150–1.705

0.001