Table 3 Univariate and multivariate analyses of factors associated with survival and recurrence in the discovery cohort

Age, ≤52 vs. >52 year

0.366

NA

0.457

NA

Gender, female vs. male

0.184

NA

0.958

NA

Hepatitis B history, yes vs. no

0.079

NA

0.124

NA

Liver cirrhosis, yes vs. no

0.010

1.493

1.152–1.937

0.002

0.057

NA

α-Fetoprotein, >200 vs. ≤200 ng/dL

<0.001

1.559

1.313–1.851

<0.001

<0.001

1.436

1.227–1.681

<0.001

ALT, >75 vs. ≤75 U/L

0.841

NA

0.313

NA

γ-GT, >50 vs. ≤50 U/L

<0.001

1.420

1.176–1.715

0.002

<0.001

1.331

1.125–1.575

0.001

Albumin, >35 vs. ≤35 g/L

<0.001

0.645

0.501–0.832

0.001

0.003

0.724

0.567–0.926

0.010

Tumor size, >5 vs. ≤5 cm

<0.001

2.052

1.715–2.455

<0.001

<0.001

1.724

1.464–2.029

<0.001

Tumor number, solitary vs. multiple

<0.001

0.683

0.544–0.857

0.001

<0.001

0.666

0.540–0.822

<0.001

Tumor differentiation, III–IV vs. I–II

<0.001

1.275

1.065–1.528

0.008

<0.001

1.290

1.091–1.525

0.003

Tumor encapsulation, complete vs. none

<0.001

1.312

1.107–1.554

0.002

<0.001

1.257

1.076–1.468

0.004

Microvascular invasion, yes vs. no

<0.001

1.425

1.187–1.712

<0.001

<0.001

1.404

1.182–1.667

<0.001

BCLC stage, 0 vs. A vs. B

<0.001

NA

<0.001

NA