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Table 3 Univariate and multivariate analyses of factors associated with survival and recurrence in the discovery cohort

From: Microvascular invasion has limited clinical values in hepatocellular carcinoma patients at Barcelona Clinic Liver Cancer (BCLC) stages 0 or B

Features Overall survival Recurrence-free survival
Univariate P Multivariate Univariate P Multivariate
HR 95% CI P HR 95% CI P
Age, ≤52 vs. >52 year 0.366    NA 0.457    NA
Gender, female vs. male 0.184    NA 0.958    NA
Hepatitis B history, yes vs. no 0.079    NA 0.124    NA
Liver cirrhosis, yes vs. no 0.010 1.493 1.152–1.937 0.002 0.057    NA
α-Fetoprotein, >200 vs. ≤200 ng/dL <0.001 1.559 1.313–1.851 <0.001 <0.001 1.436 1.227–1.681 <0.001
ALT, >75 vs. ≤75 U/L 0.841    NA 0.313    NA
γ-GT, >50 vs. ≤50 U/L <0.001 1.420 1.176–1.715 0.002 <0.001 1.331 1.125–1.575 0.001
Albumin, >35 vs. ≤35 g/L <0.001 0.645 0.501–0.832 0.001 0.003 0.724 0.567–0.926 0.010
Tumor size, >5 vs. ≤5 cm <0.001 2.052 1.715–2.455 <0.001 <0.001 1.724 1.464–2.029 <0.001
Tumor number, solitary vs. multiple <0.001 0.683 0.544–0.857 0.001 <0.001 0.666 0.540–0.822 <0.001
Tumor differentiation, III–IV vs. I–II <0.001 1.275 1.065–1.528 0.008 <0.001 1.290 1.091–1.525 0.003
Tumor encapsulation, complete vs. none <0.001 1.312 1.107–1.554 0.002 <0.001 1.257 1.076–1.468 0.004
Microvascular invasion, yes vs. no <0.001 1.425 1.187–1.712 <0.001 <0.001 1.404 1.182–1.667 <0.001
BCLC stage, 0 vs. A vs. B <0.001    NA <0.001    NA
  1. Abbreviations: ALT alanine aminotransferase, AST aspartate aminotransferase, γ-GT γ-glutamyl transpeptidase, NA not adopted, NS not significant