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Table 2 Dose reduction index (DRI)a of AR-42 and doxorubicin in osteosarcoma cell lines

From: Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis

U2OS

AR-42

Doxorubicin

 Single agent IC50 [μM]

2.55

1.45

 Combination IC50 [μM]

1.24

0.36

 DRI

2.06

4.03

D17

AR-42

Doxorubicin

 Single agent IC50 [μM]

1.46

0.32

 Combination IC50 [μM]

1.04

0.07

 DRI

1.40

4.57

  1. aDose reduction index (DRI) indicates the extent to which the concentration of a drug can be reduced in the combination to achieve an effect level similar to that achieved as a single agent
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BMC Cancer

ISSN: 1471-2407

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