Fig. 1
From: Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis
Antiproliferative effect of HDAC inhibitors AR-42 and SAHA on human and canine osteosarcoma cells. a, b Dose-dependent effects of AR-42 on cell viability after 72Â h of treatment in human (SJSA, SAOS-2, U2OS) and canine (D17, OSCA-2, OSCA-7.2, OSCA-16, OSCA-40, OSCA-36, OSCA-39.1, OSCA-50,) OS cells. c Time- and dose-dependent effects of AR-42 and SAHA on cell viability in human (U2OS and SAOS-2) and canine (D17, OSCA-2) OS cells. d Dose-dependent effects of AR-42 on cell viability after 72Â h of treatment in human (SAOS-2, U2OS) and canine (D17, OSCA-2) OS cells and normal canine osteoblasts. Cells were exposed to AR-42 or SAHA at the indicated concentrations for 24, 48 or 72Â h and cell viability assessed by MTT assay. Data presented are the average of triplicate determinations from three independent experiments