Table 3 Relationship between clinicopathological characteristics and PIK3CA mutation status
Characteristics | PIK3CA mutation status | P value | |||
|---|---|---|---|---|---|
Wild-type | Mutant | ||||
Number | % | Number | % | ||
Mean age ± SD | 62.8 ± 7.1 | 61.9 ± 5.6 | 0.643 | ||
Gender | 0.469 | ||||
Male | 140 | 83.3 | 10 | 76.9 | |
Female | 28 | 16.7 | 3 | 23.1 | |
Smoking status | 0.468 | ||||
Non-smoker | 32 | 19.0 | 1 | 7.7 | |
Smoker | 136 | 81.0 | 12 | 92.3 | |
Alcohol consumption | 1.000 | ||||
Non-drinker | 14 | 8.3 | 1 | 7.7 | |
Drinker | 154 | 91.7 | 12 | 92.3 | |
Location | 1.000 | ||||
Upper/Middle | 101 | 60.1 | 8 | 61.5 | |
Lower | 67 | 39.9 | 5 | 38.5 | |
T factor | 0.247 | ||||
1–2 | 70 | 41.7 | 3 | 23.1 | |
3–4 | 98 | 58.3 | 10 | 76.9 | |
Lymph node metastases | 1.000 | ||||
Absent | 52 | 31.0 | 4 | 30.8 | |
Present | 116 | 69.0 | 9 | 69.2 | |
TNM stage | 0.775 | ||||
I-II | 76 | 45.2 | 5 | 38.5 | |
III-IV | 92 | 54.8 | 8 | 61.5 | |
Histological differentiation | 1.000 | ||||
W/D, M/D | 146 | 86.9 | 12 | 92.3 | |
P/D | 22 | 13.1 | 1 | 7.7 | |
Lymphatic invasion | 0.400 | ||||
Absent | 81 | 48.2 | 8 | 61.5 | |
Present | 87 | 51.8 | 5 | 38.5 | |
Venous invasion | 0.470 | ||||
Absent | 35 | 20.8 | 1 | 7.7 | |
Present | 133 | 79.2 | 12 | 92.3 | |