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Table 3 Relationship between clinicopathological characteristics and PIK3CA mutation status

From: Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

Characteristics PIK3CA mutation status P value
Wild-type Mutant
Number % Number %
Mean age ± SD 62.8 ± 7.1   61.9 ± 5.6   0.643
Gender      0.469
 Male 140 83.3 10 76.9  
 Female 28 16.7 3 23.1  
Smoking status      0.468
 Non-smoker 32 19.0 1 7.7  
 Smoker 136 81.0 12 92.3  
Alcohol consumption      1.000
 Non-drinker 14 8.3 1 7.7  
 Drinker 154 91.7 12 92.3  
Location      1.000
 Upper/Middle 101 60.1 8 61.5  
 Lower 67 39.9 5 38.5  
T factor      0.247
 1–2 70 41.7 3 23.1  
 3–4 98 58.3 10 76.9  
Lymph node metastases      1.000
 Absent 52 31.0 4 30.8  
 Present 116 69.0 9 69.2  
TNM stage      0.775
 I-II 76 45.2 5 38.5  
 III-IV 92 54.8 8 61.5  
Histological differentiation      1.000
 W/D, M/D 146 86.9 12 92.3  
 P/D 22 13.1 1 7.7  
Lymphatic invasion      0.400
 Absent 81 48.2 8 61.5  
 Present 87 51.8 5 38.5  
Venous invasion      0.470
 Absent 35 20.8 1 7.7  
 Present 133 79.2 12 92.3  
  1. Abbreviations: SD standard deviation, W/D well differentiated, M/D moderately differentiated, P/D poorly differentiated