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Table 2 Sigma-2 ligands do not induce changes in blood cytology (CBC) following treatment of not tumor-bearing C57BL/6 mice

From: Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

  Control PB28 PB221 PB183 PB282 p-value
A.
 WBC (103/μL) 10.58 ± 0.2 11.11 ± 1.97 8.12 ± 0.14 6.42 ± 1.22 5.78 ± 0.78 0.9
 RBC (106/μL) 7.14 ± 0.1 10.24 ± 0.3 9.59 ± 0.71 9.24 ± 0.9 9.91 ± 0.31 0.9
 HGB (g/dL) 10.7 ± 0.7 15.65 ± 0.55 14.7 ± 0.8 14.85 ± 1.35 15 ± 0.4 0.4
 HCT (%) 36.6 ± 0.08 53.4 ± 1.5 50.35 ± 3.75 48.8 ± 3.3 51.1 ± 1.9 0.9
 MCV (fL) 51.2 ± 0.32 52.15 ± 0.05 52.5 ± 0.02 52.9 ± 1.6 51.55 ± 0.35 0.6
 MCH (pg) 15 ± 0.54 15.3 ± 0.1 15.35 ± 0.35 16.1 ± 0.1 15.15 ± 0.05 0.9
 MCHC (%) 29.2 ± 1.21 29.3 ± 0.2 29.25 ± 0.55 30.4 ± 0.7 29.4 ± 0.3 0.9
 Platelets (103/μL) 486 ± 67 643.5 ± 95.5 563 ± 17 727.5 ± 65.5 649.5 ± 167.5 0.5
B.
 BUN (mg/dL) 27 ± 0.4 32 ± 1 30.5 ± 3.5 21 ± 2 24.5 ± 0.5 0.9
 Creatinine (mg/dL) 0.34 ± 0.02 0.37 ± 0.04 0.35 ± 0.03 0.37 ± 0.04 0.35 ± 0.03 0.9
 ALT (μ/L) 260 ± 21 249 ± 9 219 ± 5 203 ± 34 221 ± 63 0.8
 AST (μ/L) 5.6 ± 0.05 5.85 ± 0.35 5.35 ± 0.05 5.4 ± 0.5 5.5 ± 0.07 0.7
 Total Protein (g/dL) 168 ± 42 194 ± 72 67.5 ± 1.5 197 ± 103 164 ± 52 0.9
 Glucose (mg/dL) 62 ± 12.5 92.5 ± 22.5 64.5 ± 7.5 125 ± 55 60 ± 10 0.4
  1. (A) Blood cytology analysis of C57BL/6 mice (n = 3 mice/group) treated with S2L and vehicle (control) for 5 days. The differences in complete blood count laboratory values between the two groups are not statistically significant. (B) Biochemical analysis of C57BL/6 mice (n = 3 mice/group) treated with sigma-2 ligands and vehicle (control) for 5 days. The differences in serum chemistries between the groups are not statistically significant