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Fig. 4 | BMC Cancer

Fig. 4

From: Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

Fig. 4

Sigma-2 ligands decrease Panc02 tumor burden in C57BL/6. One million Panc02 cells were inoculated subcutaneously into female, 10 week old C57BL/6 mice and when tumors had reached a mean diameter of 5 mm, daily sigma-2 ligand treatment or weekly gemcitabine began by i.p. injection. PB28 (a) and PB282 (e) treatment decreased tumor volume similar to gemcitabine alone. PB221 (b) and F281 (d) treatment did not confer a significantly different tumor volume than vehicle alone, while PB183 (c) treatment was not effective. Data represent Means ± SEM, n = 7-10 per group, p < 0.0001

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