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Table 4 Multivariate Cox regression analysis of independent factors influencing overall and disease free survival

From: Detection of circulating tumor cells with CK20 RT-PCR is an independent negative prognostic marker in colon cancer patients – a prospective study

Factor Category Hazard ratio 95% CI P value
Overall survival
 CK20 blooda positive vs. negative 1.94 1.0–3.7 0.042
 Age [years] <70 vs. >70 2.7 1.4–5.4 0.004
 pN stage pN0 vs. pN1/2 0.7 0.2–2.7 0.62
 pT stage pT1/2 vs. pT3/4 3.3 1.3–8.4 0.015
 UICC stage I + II vs. III + IV 6.4 1.6–26.3 0.01
Disease free survival
 CK20 blooda positive vs. negative 1.94 1.1–3.7 0.044
 pN stage pN0 vs. pN1/2 1.39 0.3–5.8 0.65
 pT stage pT1/2 vs. pT3/4 2.88 1.1–7.5 0.03
 UICC stage I + II vs. III + IV 4.9 1.0–23.7 0.045
  1. Abbreviation: CI confidence interval
  2. aTumor cell detection with CK20 RT-PCR
  3. The data in bold are regarded statistically significant (p < 0.05)