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Table 3 Number of patients with pan-cytokeratin or EpCAM positive tumor cells in the bone marrow detected with immunohistochemistry and association with patients’ characteristics (crosstabs, chi-square test, two sided)

From: Detection of circulating tumor cells with CK20 RT-PCR is an independent negative prognostic marker in colon cancer patients – a prospective study

Characteristics

Category

pan-cytokeratin

Detection rate (%)

P

EpCAM

Detection rate (%)

P

All

 

30 (134)

22.3

-

12 (61)

19.7

-

UICC stage

I

6 (30)

20.0

0.335

2 (8)

25.0

0.587

II

7 (40)

17.5

 

2 (14)

14.2

 

III

8 (39)

20.5

 

3 (22)

13.6

 

IV

9 (25)

36.0

 

5 (17)

29.4

 

pT

T1

4 (16)

25.0

0.861

2 (5)

40.0

0.575

T2

4 (25)

16.0

 

1 (10)

10.0

 

T3

17 (5)

29.4

 

7 (34)

20.6

 

T4

5 (22)

22.7

 

2 (12)

16.4

 

pN

N0

14 (75)

18.6

0.324

5 (24)

20.8

0.253

N1

8 (35)

22.8

 

2 (21)

9.5

 

N2

8 (24)

33.3

 

5 (16)

31.2

 

Grading

G1

1 (9)

11.1

0.702

0 (3)

0

0.108

G2

23 (99)

23.23

 

12 (47)

25.5

 

G3

6 (26)

23.1

 

0 (11)

0

 

Liver

M0

21 (104)

20.1

0.07

7 (44)

15.9

0.287

Metastases

M1

9 (30)

30

 

5 (17)

29.4