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Table 1 Patients’ clinical and pathological characteristics and univariate analysis of factors influencing the 5-year overall survival (OS) and disease free survival (DFS) rate

From: Detection of circulating tumor cells with CK20 RT-PCR is an independent negative prognostic marker in colon cancer patients – a prospective study

Characteristics Category n % 5y-OS (%) P 5y-DFS (%) P
CK20 blood positive 112 37.4 68 0.002 78 0.021
(n = 299) negative 187 62.6 85   89  
CK20 bone marrow positive 81 35.7 71 0.09 85 0.419
(n = 227) negative 146 63.3 79   86  
pan-cytokeratin positive 30 22.4 59 0.048 61 0.041
(n = 134) negative 104 77.6 76   80  
EpCAM positive 12 19.7 55 0.958 44 0.548
(n = 61) negative 49 80.3 64   72  
Sex male 168 56.2 79 0.70 84 0.563
female 131 43.8 77   87  
Age [years] <70 160 53.5 82 0.045 88 0.332
> 70 139 46.5 74   83  
UICC stage I 87 29.1 98 <0.001 99 <0.001
II 94 31.4 89   90  
III 80 26.8 71   77  
IV 38 12.7 24   48  
pT T1 42 14.0 98 <0.001 98 0.005
T2 70 23.4 89   94  
T3 159 53.2 73   80  
T4 28 9.4 47   75  
pN N0 190 63.6 91 <0.001 93 <0.001
N1 65 21.7 64   76  
N2 44 14.7 46   64  
Grading G1 21 7.0 95 0.054 76 0.704
G2 236 78.9 79   85  
G3 42 14.1 65   91  
Operation right hemicolectomy 108 36.3     
left hemicolectomy 36 12.0     
transverse colon resection 18 6.0     
sigmoid colon resection 122 40.8     
subtotal colectomy 15 5.0     
  1. The data in bold are regarded statistically significant (p < 0.05)