Table 2 List of top 5 upstream regulator genes implicated in MCF-7/Twist cells, MCF-7/Twist primary tumors, and MCF-7/Twist metastases
Upstream Regulator Genes | P-value of overlap | Corrected z-score | Prediction |
|---|---|---|---|
MCF-7/Twist cells | |||
 Estrogen receptor | 1.49E-18 | −5.712 | Inhibited |
 NUPR1 | 2.34E-14 | 1.843 |  |
 TP53 | 7.63E-14 | −0.497 |  |
 TNF | 7.66E-14 | 3.849 | Activated |
 SMARCA4 | 9.56E-14 | 2.028 | Activated |
Primary tumors | |||
 ERBB2 | 3.71E-06 | 0.231 |  |
 CD24 | 4.63E-06 | 1.199 |  |
 TP73 | 1.39E-05 | −1.712 |  |
 TGFB1 | 2.48E-05 | −0.534 |  |
 HSPA9 | 2.54E-05 | −0.2 |  |
Metastasis | |||
 Lh | 7.23E-05 | −1.027 |  |
 CXCL12 | 1.54E-04 | −2.071 | Inhibited |
 NUP107 | 4.01E-04 | 1.052 |  |
 FOXA2 | 2.03E-03 |  |  |
 FSH | 2.36E-03 | −0.698 |  |