Table 1 List of top 5 canonical pathways that are implicated in MCF-7/Twist cell line, MCF-7/Twist primary tumors, and MCF-7/Twist metastases
Canonical Pathways | P-value | Overlap (%) | Overlap (number of genes) |
|---|---|---|---|
MCF-7/Twist cells | |||
 Oncostatin M Signaling | 3.29E-08 | 58.8% | 20/34 |
 Neuregulin Signaling | 7.25E-08 | 41.2% | 35/85 |
 IL-8 Signaling | 1.54E-07 | 32.2% | 59/183 |
 NRF2-mediated Oxidative Stress Response | 1.69E-07 | 32.6% | 57/175 |
 GM-CSF Signaling | 3.90E-07 | 44.3% | 27/61 |
Primary tumors | |||
 Role of NFAT in Cardiac Hypertrophy | 2.38E-06 | 40.8% | 71/174 |
 Signaling by Rho Family GTPases | 4.87E-06 | 38.1% | 88/231 |
 IGF-1 Signaling | 5.96E-06 | 45.8% | 44/96 |
 α-Adrenergic Signaling | 7.05E-06 | 47.1% | 40/85 |
 Dopamine-DARPP32 Feedback in cAMP Signaling | 7.61E-06 | 40.8% | 64/157 |
Metastases | |||
 Role of Tissue Factor in Cancer | 5.36E-07 | 34.6% | 37/107 |
 Molecular Mechanisms of Cancer | 6.94E-06 | 24.0% | 86/358 |
 Role of NFAT in Cardiac Hypertrophy | 8.39E-06 | 28.2% | 49/174 |
 CXCR4 Signaling | 9.26E-06 | 29.1% | 44/151 |
 Pancreatic Adenocarcinoma Signaling | 1.01E-05 | 32.1% | 34/106 |