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Table 1 List of top 5 canonical pathways that are implicated in MCF-7/Twist cell line, MCF-7/Twist primary tumors, and MCF-7/Twist metastases

From: Genomic pathways modulated by Twist in breast cancer

Canonical Pathways P-value Overlap (%) Overlap (number of genes)
MCF-7/Twist cells
 Oncostatin M Signaling 3.29E-08 58.8% 20/34
 Neuregulin Signaling 7.25E-08 41.2% 35/85
 IL-8 Signaling 1.54E-07 32.2% 59/183
 NRF2-mediated Oxidative Stress Response 1.69E-07 32.6% 57/175
 GM-CSF Signaling 3.90E-07 44.3% 27/61
Primary tumors
 Role of NFAT in Cardiac Hypertrophy 2.38E-06 40.8% 71/174
 Signaling by Rho Family GTPases 4.87E-06 38.1% 88/231
 IGF-1 Signaling 5.96E-06 45.8% 44/96
 α-Adrenergic Signaling 7.05E-06 47.1% 40/85
 Dopamine-DARPP32 Feedback in cAMP Signaling 7.61E-06 40.8% 64/157
Metastases
 Role of Tissue Factor in Cancer 5.36E-07 34.6% 37/107
 Molecular Mechanisms of Cancer 6.94E-06 24.0% 86/358
 Role of NFAT in Cardiac Hypertrophy 8.39E-06 28.2% 49/174
 CXCR4 Signaling 9.26E-06 29.1% 44/151
 Pancreatic Adenocarcinoma Signaling 1.01E-05 32.1% 34/106
  1. Pathways are ranked by P-value