Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer

BMC Cancer

Table 4 Association of MRN complex with clinicopathological factors and MMR status

Variable	n	MRN complex negative n (%)	p-value
FIGO stage
Early (I & II)	40	20 (50)	0.017^a
Late (III & IV)	88	32 (36.4)	0.017^a
Histologic subtype
High-grade serous	67	17 (25.4)	0.001^b
Mucinous	14	9 (64.3)	0.001^b
Clear cell	25	16 (64.0)
Endometrioid	28	13 (46.4)
Grade
Low-grade	33	19 (57.6)	0.04^a
High-grade	101	36 (35.6)	0.04^a
Kurman model’
Type I	58	35 (60.3)	0.0001^a
Type II	76	20 (26.3)	0.0001^a
MMR status
Negative	28	25 (89.3)	<0.0001^a
Positive	103	27 (26.2)	<0.0001^a
KRAS status
wt	114	43 (37.7)	0.082^a
Mutation	14	9 (64.3)	0.082^a
TP53 status
wt	58	24 (41.4)	0.9^a
Mutation	70	28 (40.0)	0.9^a

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