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Table 1 Clinicopathologic Characteristics of three groups according to Ki67-LI level

From: Prognostic significance of Ki67 in Chinese women diagnosed with ER+/HER2 breast cancers by the 2015 St. Gallen consensus classification

Characteristic

Ki67 ≤ 10%

n = 342

10% < Ki67 < 30%

n = 281

Ki67 ≥ 30%

n = 316

Total

N = 939

P value

Associated events-no.(%)

10(2.9)

20(7.1)

49(15.5)

79(8.4)

 

Age

     

 Median(IQT)-yr

49(23–86)

48(24–91)

47(22–84)

48(22–91)

0.166

 Distribution-no.(%)

    

0.013

 < 35

19(5.6)

15(5.3)

31(9.8)

65(6.9)

 

 35–50

160(46.8)

148(52.7)

163(51.6)

471(50.2)

 

 51–65

122(35.7)

93(33.1)

102(32.3)

317(33.8)

 

 > 65

41(12.0)

25(8.9)

20(6.3)

86(9.2)

 

Menopausal status-no.(%)

    

0.011

 Pre

171(50.0)

122(43.4)

176(55.7)

469(49.9)

 

 Post/Peri

171(50.0)

159(56.6)

140(44.3)

470(50.0)

 

Histology-no.(%)

    

<0.001

 IDC

273(79.8)

236(84.0)

297(94.0)

806(85.8)

 

 ILC

10(2.9)

10(3.6)

6(1.9)

26(2.8)

 

 Mucinous

25(7.3)

13(4.6)

4(1.3)

42(4.5)

 

 Other invasive histology

34(9.9)

22(7.8)

9(2.8)

65(6.9)

 

pT-no./total no.(%)

    

<0.001

 1

239/336(71.1)

181/276(65.6)

159/307(51.8)

579/919(63.0)

 

 2

91/336(27.1)

86/276(31.2)

139/307(45.3)

316/919(34.4)

 

 3

6/336(1.8)

9/276(3.3)

9/307(2.9)

24/919(2.6)

 

Node-no.(%)

    

0.022

 N0

249(72.8)

180(64.1)

202(63.9)

631(67.2)

 

 N1

93(27.2)

101(35.9)

114(36.1)

308(32.8)

 

LVI-no.(%)

    

0.074

 Positive

49(14.3)

59(21.0)

61(19.3)

169(18.0)

 

 Negative

293(85.7)

222(79.0)

255(80.7)

770(82.0)

 

Grade-no./total no.(%)

    

<0.001

 I/II

269/289(93.1)

189/241(78.4)

137/282(48.6)

595/812(73.3)

 

 III

20/289(6.9)

52/241(21.6)

145/282(51.4)

217/812(26.7)

 

PgR-no.(%)

    

<0.001

 < 20%

58(17.0)

55(19.6)

119(37.7)

232(24.7)

 

 ≥ 20%

284(83.0)

226(80.4)

197(62.3)

707(75.3)

 

Surgery-no.(%)

    

0.479

 BCS

202(59.1)

178(63.3)

187(59.2)

567(60.4)

 

 Mastectomy

140(40.9)

103(36.7)

129(40.8)

372(39.6)

 

Chemotherapy-no.(%)

    

<0.001

 Yes

252(73.7)

234(83.3)

290(91.8)

776(82.6)

 

 No

90(26.3)

47(16.7)

26(8.2)

163(17.4)

 

Radiotherapy-no.(%)

    

0.033

 Yes

237(69.3)

217(77.2)

243(76.9)

697(74.2)

 

 No

105(30.7)

64(22.8)

73(23.1)

242(25.8)

 
  1. IQT interquartile range, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, LVI lymphovascular invasion, PgR progesterone receptor, BCS breast-conserving surgery