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Fig. 1 | BMC Cancer

Fig. 1

From: PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells

Fig. 1

Effects of EP4 ligands and C3L5-CM on proliferation and migration of RMLEC. Western blots for a Lyve-1, Prox-1 and b CD-31 were performed with RMLEC lysate. For both Lyve-1 and Prox-1, mouse lung extract and MCF-7 cell lysate were used as respective + ve and –ve controls. For CD-31, HUVEC and HEK-293 cell lysates were used as respective + ve and –ve controls. c proliferation (BrdU incorporation) and d trans-well migration assays were performed to assess the effects of PGE2, PGE1OH and C3L5-CM on RMLEC. Error bars represent mean ± SEM of three different experiments. (*) represents p < 0.05

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