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Table 5 Toxicity profile for the NSCLC with brain metastasis patients treated by CRT and RT

From: The efficacy and roles of combining temozolomide with whole brain radiotherapy in protection neurocognitive function and improvement quality of life of non-small-cell lung cancer patients with brain metastases

Side effects/N (%) RCT arm (N = 129) RT arm (N = 109) P for all grades P for grade III/IV
All grades Grade III/IV All grades Grade III/IV
Fatigue 81 (62.8) 16 (12.4) 68 (62.4) 12 (11.0) 0.95 0.74
Anorexia 64 (49.6) 14 (10.9) 47 (43.1) 9 (8.3) 0.29 0.50
Diarrhea 18 (13.9) 0 (0%) 12 (11.0) 0 (0%) 0.50 NA
Nausea 88 (68.2) 29 (22.5) 83 (76.1) 20 (18.3) 0.18 0.43
Vomiting 69 (53.5) 14 (10.9) 61 (56.0) 13 (11.9) 0.70 0.80
Headache 55 (42.6) 13 (10.1) 43 (39.4) 11 (10.1) 0.62 0.99
Anemia 72 (55.8) 5 (3.9) 61 (56.0) 3 (2.8) 0.98 0.91
Neutropenia 66 (51.2) 13 (10.1) 59 (54.1) 10 (9.2) 0.65 0.81
Thrombocytopenia 61 (47.3) 4 (3.1) 51 (46.8) 2 (1.8) 0.94 0.84