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Table 2 Multivariate analysis : Factors predictive of biopsy

From: Biopsy of breast cancer metastases: patient characteristics and survival

Variable

 

P value

Adjusted OR (95.0% CI for OR)

Years of metastatic recurrence

2000–04

 

Ref.

2005–09

.000

3.79 (1.94–7.40)

2010–14

.000

10.67 (5.13–22.22)

Time to recurrence(years)

<3 years

 

Ref.

> = 3 years

.000

3.20 (1.78–5.76)

Stage at initial diagnosis

Stage IIB-III

 

Ref.

Stage 0- IIA

.012

1.89 (1.15–3.10)

Site of metastasis at recurrence

No locally advanced disease

 

Ref.

Locally advanced disease

.011

1.90 (1.16–3.10)

HR &HER2 at initial diagnosis

HR+/HER2+

 

Ref.

HR-/HER2-

.349

1.68 (0.57–4.93)

HR-/HER2+

.813

1.15 (0.35–3.74)

HR+/HER2-

.021

2.83 (1.17–6.83)

Missing HR or/and HER2

.000

6.78 (2.49–18.45)

  1. All other variables were not significant
  2. HR hormone receptors, HER2 human epidermal growth factor receptor 2