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Fig. 8 | BMC Cancer

Fig. 8

From: Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1

Fig. 8

PKD1 silencing by lentiviral vector based shRNA transduction in the M2 metastatic melanoma cells. Protein extracts from parental (M2), lentiviral PKD1-specific (clones P2, P3, P4, P5, P6 and P7) and control (clones C1 and C2) shRNA-transduced M2 cells were analyzed by western blot using anti-PKD1 and anti-actin antibodies. The results presented are those of typical experiments. The histograms represent quantitative analysis of PKD1 expression normalized to C1 control clone. The results presented are the means ± SD for two independent experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001 versus C1 and C2 control clones

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