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Fig. 7 | BMC Cancer

Fig. 7

From: Protein kinase C inhibitor Gö6976 but not Gö6983 induces the reversion of E- to N-cadherin switch and metastatic phenotype in melanoma: identification of the role of protein kinase D1

Fig. 7

Protein kinase D1 expression positively correlates with N-cadherin and negatively correlates with E-cadherin in primary and metastatic melanoma cells. Protein extracts from primary (T1 and I5) and metastatic (G1, M2 and M4T2) melanoma cells were analyzed by western blot using anti-PKD1, anti-E-cadherin, anti-N-cadherin and anti-actin antibodies. a. The results presented are those of typical experiments. The histograms represent quantitative analysis of PKD1, N-cadherin and E-cadherin expression from two independent experiments. b. The table represents the relationship between PKD1 protein levels and E-cadherin and N-cadherin levels in the melanoma cell lines

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