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Fig. 5 | BMC Cancer

Fig. 5

From: Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through ROS generation and inhibits cell migration

Fig. 5

Compound 3c inhibits migration of cancer cells. a. SW620 cells were seeded in the designated upper chamber and real time migrations of cells were monitored using xCELLigence RTCA-DP system. b. HT-29 cells were seeded into a 6-well plate and allowed to grow to 90% confluency in complete media. Cell monolayers were wounded by tips (1 mm) and washed with PBS. Media replaced with fresh media with either DMSO or 3c and put back into the incubator for 48 h. Cells were monitored by microscope and digital images were captured. All the experiments were repeated three times and the representative images were shown. c: HT-29; d: SW620; e: HT-29 cells were pretreated with 3c (5 μM) and stimulated with TGFβ, total cell lysates were immunoblotted with the indicated antibodies

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