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Fig. 3 | BMC Cancer

Fig. 3

From: Chemotherapy-induced Sinusoidal Injury (CSI) score: a novel histologic assessment of chemotherapy-related hepatic sinusoidal injury in patients with colorectal liver metastasis

Fig. 3

Aberrant expression of CD34, SMA, and GS in cases with sinusoidal obstruction syndrome were used to calculate the CSI score. a In case 12, the immunohistochemistry for CD34 showed confluent sinusoidal staining extending from the periportal to midzonal and centrizonal areas (×100). This is an example of a immunohistochemistry grade 3 for CD34. b Immunohistochemical stain for SMA in the same case showed confluent subsinusoidal staining in multiple areas (×200), which is also an example of a grade 3 staining intensity. c Immunohistochemistry conducted on case 14 showed GS expression adjacent to an obliterated sublobular vein (arrow) that was expanded (×100) compared to the normal perivenular GS staining pattern and was also give an immunohistochemistry score of 3. d In Case 19, aberrant confluent GS expression is seen in midzonal and periportal areas; another example of a grade 3 pattern of staining (asterisks, central veins; arrow, portal tract; ×100)

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BMC Cancer

ISSN: 1471-2407

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