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Fig. 2 | BMC Cancer

Fig. 2

From: Chemotherapy-induced Sinusoidal Injury (CSI) score: a novel histologic assessment of chemotherapy-related hepatic sinusoidal injury in patients with colorectal liver metastasis

Fig. 2

Common histologic features of SOS. a Shown are changes typical of sinusoidal obstruction (Case 12). Bridging bands of congestion were observed connecting centrizonal areas (H&E, ×40). b In the same case, a trichrome stain highlights prominent fibrosis extending along centrilobular sinusoids and also shows atrophic hepatocyte trabeculae (trichrome stain, ×200). c Nodular regenerative hyperplasia. In some cases (e.g., Case 6), the hepatic parenchyma showed diffuse transformation into small nodules with little to no fibrosis (reticulin stain, ×40). d Venous occlusion. Case 14 showed complete fibrous obliteration of the central veins (H&E, ×100), which was further confirmed with Verhoeff–Van Gieson staining (inset, ×100)

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