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Table 5 Performance and internal validation of all the multivariate cox proportional hazard models

From: Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma – clinical application of health-related quality-of-life data

MV model

c-index

95% CI

Mean c-index from 1000 bootstraps

95% CI based on 1000 bootstrap samples

Optimism

Optimism in %

M1

0.7872

0.7648–0.8095

0.7891

0.7678–0.8111

0.0019

0.24%

M2

0.7842

0.7617–0.8066

0.7878

0.7660–0.8103

0.0036

0.46%

M3

0.7817

0.7591–0.8043

0.7840

0.7626–0.8066

0.0023

0.29%

M4

0.7810

0.7588–0.8032

0.7841

0.7638–0.8056

0.0031

0.40%

M5

0.7821

0.7598–0.8043

0.7839

0.7621–0.8072

0.0018

0.23%

M6

0.7791

0.7564–0.8018

0.7715

0.7604–0.8034

−0.0076

−0.96%

  1. MV multivariate, CI confidence interval
  2. M1: the multivariate cox model using QLQ-C30 as continuous variables
  3. M2: the multivariate cox model using QLQ-C30 as dichotomized variables
  4. M3: the multivariate cox model using C30 index score
  5. M4: the multivariate cox model using QLQ-HCC18 as continuous variables
  6. M5: the multivariate cox model using QLQ-HCC18 as dichotomized variables
  7. M6: the multivariate cox model using HCC18 index score