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Table 1 Baseline characteristics and univariate Cox regression analyses of overall survival for patients with complete HRQOL data (n = 472)

From: Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma – clinical application of health-related quality-of-life data

  n % HR 95% C.I. p-value
Demographics/clinical
 Age < = 65 328 69 0.909 0.730–1.131 0.3898
 Male gender 419 89 1.299 0.919–1.835 0.1381
 ECOG ≥ 2 29 6 2.885 1.927–4.317 <0.0001
Laboratory
 Hemoglobin <10g/dL 27 6 1.294 0.840–1.995 0.2424
 White cell count >10×109/L 64 14 2.507 1.885–3.333 <0.0001
 Platelet count < 100×109/L 33 7 1.696 1.158–2.485 0.0067
 International normalized ratio >1.4 36 8 1.410 0.945–2.104 0.0922
 Creatinine ≥ ULN 67 14 1.115 0.833–1.491 0.4644
 Bilirubin ≥ 20umol/l 239 51 1.974 1.594–2.445 <0.0001
 Albumin ≤35g/l 182 39 2.186 1.765–2.708 <0.0001
 Alanine aminotransferase >2xULN 81 17 1.567 1.201–2.044 0.0009
 Alkaline phosphatase >2xULN 145 31 2.417 1.938–3.014 <0.0001
Underlying liver condition
 Hepatitis B surface antigen + 386 82 1.196 0.908–1.575 0.2029
 Hepatitis C antibody + 30 6 0.641 0.403–1.019 0.0600
 Ascites 278 59 0.894 0.721–1.107 0.3036
 Cirrhosis (radiological) 122 26 2.237 1.775–2.820 <0.0001
 Child-Pugh class
  A 319 68 1.000 - -
  B 130 28 2.187 1.740–2.750 <0.0001
  C 23 4 4.360 2.774–6.854 <0.0001
Tumor characteristics
 α-fetoprotein ≥200 mg/ml 250 53 2.318 1.865–2.882 <0.0001
 Tumor morphology
  Uninodular 122 26 1.000 - -
  Multinodular 143 30 2.097 1.509–2.914 <0.0001
 Diffuse 207 44 4.360 3.027–3.822 <0.0001
 Extrahepatic metastasis (nodal or distant) 108 23 3.003 2.360–3.822 <0.0001
 Portal vein thrombosis 152 32 3.647 2.899–4.587 <0.0001
1st line Treatment
 Curative 83 18 1.000 -  
 Palliative or best supportive care alone 389 82 5.802 3.820–8.810 <0.0001
 Surgical treatment 54 12 1.000 -  
 Local ablative therapies 29 6 2.526 1.131–5.643 0.0238
 Trans-arterial therapies 116 25 4.597 2.446–8.637 <0.0001
 Systemic therapies 91 19 10.209 5.380–19.372 <0.0001
 Best supportive care alone 182 38 15.624 8.442–28.914 <0.0001
  1. ECOG Eastern Cooperative Oncology Group performance status, ULN upper limit of normal, CI confidence interval, HR hazard ratio