Table 2 Metabolic toxicities
Toxicity | Temsirolimus (n = 31) | Everolimus (n = 44) | Time to highest toxicity grade, days | Highest absolute change from baseline (%) | ||
|---|---|---|---|---|---|---|
All grade n (%) | Grade 3/4 n (%) | All grade n (%) | Grade 3/4 n (%) | Median (range) | Median (range) | |
Lymphopenia | 13 (42) | 4 (13) | 25 (57) | 9 (20) | 56 (28; 644) | −31 (−79; 168) |
Increase in serum creatinine | 14 (45) | - | 27 (61) | - | 90 (28; 420) | 9.5 (−32; 78) |
Hyperglycemia | 9 (29) | 2 (6) | 24 (54) | 6 (14) | 56 (28; 756) | 18 (−44; 346) |
Hypophosphatemia | 2 (6) | 1 (3) | 11 (25) | 3 (7) | 56 (28; 168) | −22 (−55; 16) |
Increase in ASAT | 4 (13) | - | 14 (32) | 1 (2) | 28 (14-; 280) | 47 (−75; 552) |
Increase in ALAT | 2 (6) | - | 14 (32) | 2 (4) | 28 (28; 308) | 75 (−68; 1883) |
Hypercholesterolemia | 13 (42) | - | 31 (70) | 3(7) | 28 (28; 392) | 32 (−51; 125) |
Hypertriglyceridemia | 14 (45) | - | 31 (70) | - | 56 (14; 224) | 85 (−58; 375) |