Skip to main content

Table 3 Univariate analysis of overall survival

From: A matched-pair study comparing whole-brain irradiation alone to radiosurgery or fractionated stereotactic radiotherapy alone in patients irradiated for up to three brain metastases

 

At 1 year (%)

At 2 years (%)

At 3 years (%)

P

Type of irradiation

 WBI alone

40

17

11

 

 RS/FSRT alone

45

12

7

0.63

Age

  ≤ 60 years

52

17

10

 

  > 60 years

32

10

7

0.019

Gender

 Female

44

18

13

 

 Male

41

8

n.a.

0.20

ECOG performance score

 0–1

50

17

12

 

 2

26

7

2

<0.001

Nature of tumor

 Breast cancer

62

32

19

 

 Non-small-cell lung cancer

41

11

6

 

 Small-cell lung cancer

70

n.a.

n.a.

 

 Kidney cancer

31

21

21

 

 Melanoma

27

6

n.a.

 

 Cancer of unknown primary

47

0

0

 

 Gastrointestinal cancers

28

0

0

 

 Gynecological cancers

0

0

0

<0.001

Brain metastases number

 1

47

16

10

 

 2–3

37

12

7

0.06

Extra-cerebral spread

 No

54

17

11

 

 Yes

31

11

7

<0.001

Period from cancer detection to irradiation

  ≤ 15 months

40

10

4

 

  > 15 months

45

18

14

0.19

RPA-class

 1

61

19

14

 

 2

31

11

5

<0.001

  1. n.a. not available; according to Bonferroni correction, p-values <0.0056 were considered significant