Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

Table 2 Multivariate analysis for prognostic significance of clinicopathologic factors and tumor LINE-1 methylation in metastatic CRC

Variables	Hazard ratio	(95% CI)	p-value
Female	0.85	(0.38–1.91)	0.70
Older patients^a	0.63	(0.28–1.41)	0.26
Rectum (vs. colon)	0.84	(0.38–1.85)	0.66
Well differentiation (vs. others)	0.95	(0.26–3.41)	0.94
Recurrence (vs. stage IV)	0.81	(0.31–2.14)	0.67
Multiple organs (vs. one organ) metastasis	0.85	(0.34–2.08)	0.72
Previous treatment with 5-FU	1.62	(0.55–4.77)	0.38
Second line (vs. first line) chemotherapy	1.08	(0.37–3.11)	0.89
LINE-1 hypomethylation ^b	2.74	(1.19–6.29)	0.018

^aAge: older (>65 y) versus younger (65 y ≥) patients
^bThe levels of tumor LINE-1 methylation were classified as hypomethylation versus hypermethylation based on the cutoff value (51.7%) determined by the ROC curve (Fig. 3a)

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