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Fig. 5 | BMC Cancer

Fig. 5

From: Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer

Fig. 5

Combined effect of oxaliplatin and 5-FU treatment on LINE-1 expressing and non-expressing colon cancer cells. SW480 (LINE-1 expressing) and HCT116 (LINE-1 non-expressing) cells were treated with oxaliplatin (2 μM) alone, 5-FU (1 μM, 2 μM) alone, or a combination of both. For the combined treatment, the respective cells were treated sequentially with 2 μM oxaliplatin for 2 h and then with 5-FU (1 μM or 2 μM) for 48 h and 120 h. γH2A.X foci were measured following the respective treatments. Statistical differences between the data are shown in Additional file 4: Figure S2

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