|
Covariate
|
P value
|
Hazard ratio (95% CI)
|
|---|
|
Female Sex
|
0.20
|
0.443 (0.129–1.53)
|
|
High KPS (≥70)
|
0.43
|
0.656 (0.231–1.86)
|
|
Controlled systemic disease/no extracranial metastasis
|
0.62
|
1.35 (0.417–4.35)
|
|
Long interval from primary diagnosis to SRS (>12 months)
|
0.48
|
1.41 (0.549–3.60)
|
|
Chemotherapy
|
0.25
|
0.423 (0.097–1.84)
|
|
Solitary metastasis
|
0.21
|
0.534 (0.206–1.42)
|
|
Small cumulative PIV (≤5 mL)
|
0.15
|
0.438 (0.144–1.33)
|
|
Two-session SRS
|
0.26
|
0.426 (0.095–1.91)
|
- SRS stereotactic radiosurgery, CI confidence interval, KPS Karnofsky performance scale, PIV prescription isodose volume
