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Table 4 Analysis of factors predicting neurological death-free survival after SRS (Fine-Gray proportional hazards model)

From: Is upfront stereotactic radiosurgery a rational treatment option for very elderly patients with brain metastases? A retrospective analysis of 106 consecutive patients age 80 years and older

Covariate P value Hazard ratio (95% CI)
Female Sex 0.20 0.443 (0.129–1.53)
High KPS (≥70) 0.43 0.656 (0.231–1.86)
Controlled systemic disease/no extracranial metastasis 0.62 1.35 (0.417–4.35)
Long interval from primary diagnosis to SRS (>12 months) 0.48 1.41 (0.549–3.60)
Chemotherapy 0.25 0.423 (0.097–1.84)
Solitary metastasis 0.21 0.534 (0.206–1.42)
Small cumulative PIV (≤5 mL) 0.15 0.438 (0.144–1.33)
Two-session SRS 0.26 0.426 (0.095–1.91)
  1. SRS stereotactic radiosurgery, CI confidence interval, KPS Karnofsky performance scale, PIV prescription isodose volume