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Table 4 Analysis of factors predicting neurological death-free survival after SRS (Fine-Gray proportional hazards model)

From: Is upfront stereotactic radiosurgery a rational treatment option for very elderly patients with brain metastases? A retrospective analysis of 106 consecutive patients age 80 years and older

Covariate

P value

Hazard ratio (95% CI)

Female Sex

0.20

0.443 (0.129–1.53)

High KPS (≥70)

0.43

0.656 (0.231–1.86)

Controlled systemic disease/no extracranial metastasis

0.62

1.35 (0.417–4.35)

Long interval from primary diagnosis to SRS (>12 months)

0.48

1.41 (0.549–3.60)

Chemotherapy

0.25

0.423 (0.097–1.84)

Solitary metastasis

0.21

0.534 (0.206–1.42)

Small cumulative PIV (≤5 mL)

0.15

0.438 (0.144–1.33)

Two-session SRS

0.26

0.426 (0.095–1.91)

  1. SRS stereotactic radiosurgery, CI confidence interval, KPS Karnofsky performance scale, PIV prescription isodose volume