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Table 3 Analysis of factors predicting patient survival after SRS (Cox proportional hazards model)

From: Is upfront stereotactic radiosurgery a rational treatment option for very elderly patients with brain metastases? A retrospective analysis of 106 consecutive patients age 80 years and older

Covariate (No. of patients) MST (months) P value Hazard ratio (95% CI)
Sex   0.028 0.569 (0.344–0.942)
 Female (37) 8.9   
 Male (69) 4.7   
KPS   < .001 0.444 (0.279–0.706)
 KPS ≥ 70 (56) 9.7   
 KPS < 70 (50) 4.5   
Controlled systemic disease/no extracranial metastasis   < .001 0.361 (0.206–0.632)
 Yes (25) 18.0   
 No (81) 4.7   
Interval from primary diagnosis to SRS   0.053 0.687 (0.448–1.05)
 Long > 12 months (54) 8.8   
 Short ≤ 12 months (52) 4.4   
Chemotherapy   0.806 1.08 (0.603–1.92)
 Yes (31) 12.8   
 No (75) 5.2   
No. of metastases   0.513 0.864 (0.557–1.34)
 Solitary (52) 6.9   
 Multiple (54) 7.1   
Cumulative PIV   0.375 1.25 (0.762–2.06)
 Small ≤ 5 mL (45) 7.7   
 Large > 5 mL (61) 5.4   
Type of intervention   0.269 1.47 (0.744–2.89)
 Two-session (15) 4.0   
 Single session (91) 7.2   
  1. SRS stereotactic radiosurgery, MST median survival time, CI confidence interval, KPS Karnofsky performance scale, PIV prescription isodose volume