Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia

BMC Cancer

Table 1 Immunohistochemical quantification data

PDE subtype	Sample Size, CTRL vs CRN	Mean (±SEM) CTRL vs CRN	p-value
PDE3A	14 vs 16	11404 (1209) vs 8313 (762)	0.035
PDE3B	14 vs 16	4098 (829) vs 4200 (908)	0.936
PDE4A	14 vs 16	16740 (1997) vs 13786 (1203)	0.203
PDE4B^a	14 vs 16	4276 (640) vs 6723 (724)	0.019
PDE4C	14 vs 16	16954 (1458) vs 15439 (1159)	0.418
PDE4D	14 vs 15	8473 (1442) vs 6923 (936)	0.369
PDE5A	14 vs 16	16614 (1514) vs 14736 (1365)	0.363

Only PDE4B elicited significantly altered expression and quantification levels. P-values for PDE3A and PDE3B were calculated using Mann–Whitney rank test. All other p-values were obtained using the students t-test. A sample from the CRN group was removed for PDE4D after both blinded investigator concluded that quantification was not possible
^aMarks PDE subtypes with significantly elevated expression levels

ISSN: 1471-2407