|
Toxicities (RTOG Grade)
|
h-R3/RT (N = 52) [n (%)]
|
CDDP/RT (N = 52) [n (%)]
|
P Value*
|
|---|
|
WBC
| | |
0.048*
|
|
(1&2)
|
32 (61.5%)
|
32 (61.5%)
| |
|
(3&4)
|
1 (1.9%)
|
7 (13.5%)
| |
|
PLT
| | |
0.752
|
|
(1&2)
|
19 (36.5%)
|
18 (34.6%)
| |
|
(3&4)
|
1 (1.9%)
|
2 (3.8%)
| |
|
HB
| | |
0.499
|
|
(1&2)
|
27 (51.9%)
|
26 (50%)
| |
|
(3&4)
|
0 (0.00%)
|
0 (0.00%)
| |
|
ALT
| | |
0.294
|
|
(1&2)
|
10 (19.1%)
|
8 (11.9%)
| |
|
(3&4)
|
0 (0.00%)
|
0 (0.00%)
| |
|
AST
| | |
0.197
|
|
(1&2)
|
10 (19.2%)
|
5 (9.6%)
| |
|
(3&4)
|
0 (0.00%)
|
0 (0.00%)
| |
|
GGT
| | |
0.166
|
|
(1&2)
|
9 (17.3%)
|
5 (9.6%)
| |
|
(3&4)
|
0 (0.00%)
|
0 (0.00%)
| |
|
Dermatitis
| | |
0.445
|
|
(1&2)
|
33 (63.5%)
|
44 (84.6%)
| |
|
(3&4)
|
2 (3.8%)
|
1 (1.9%)
| |
|
Rash
| | |
0.248
|
|
(1&2)
|
5 (9.6%)
|
3 (5.8%)
| |
|
(3&4)
|
1 (1.9%)
|
0 (0.00%)
| |
|
Mucositis
| | |
0.093
|
|
(1&2)
|
21 (40.4%)
|
26 (50%)
| |
|
(3&4)
|
30 (57.7%)
|
25 (48.1%)
| |
|
Taste change
| | |
0.763
|
|
yes
|
46 (88.5%)
|
47 (90.4%)
| |
|
no
|
6 (11.5%)
|
5 (9.6%)
| |
|
Vomit
| | |
0.000*
|
|
only nausea
|
12 (23.1%)
|
2 (3.8%)
| |
|
nausea and vomit
|
5 (9.6%)
|
43 (78.8%)
| |
|
Weight loss
| | |
0.249
|
|
(1&2)
|
26 (50.0%)
|
30 (57.7%)
| |
|
(3&4)
|
13 (25.0%)
|
15 (28.8%)
| |
- Abbreviations: RT radiotherapy, h-R3/RT nimotuzumab and radiotherapy, CDDP/RT cisplatin and radiotherapy. WBC white blood cell, PLT Platelets, HB hemoglobin, ALT alanine transaminase, AST glutamic-oxalacetic transaminease, GGT gamma glutamyl transpeptidase
- *All p values were obtained by the paired rank sum test
