Table 2 Genes with more than 2-fold regulation after knockdown of ERβ: Gene ontology (GO)
GO-Term | GO-Term id | P-value | List of observed genes |
|---|---|---|---|
A. GO Cellular components | |||
Extracellular matrix part | GO:0044420 | 4,91E-04 | MFAP5, TNC, MMP13, LOX, NID1 |
Extracellular region | GO:0005576 | 3,71E-05 | MFAP5, AQP1, TNC, IGFBP7, NPNT, MMP13, LOX, CXCL14, TNFSF15, ANGPT1, TGFB2, MTRNR2L2, FLRT3, SEMA3D, TGFB1, NID1, DKK1, CYTL1, IGFBP5, SFN |
Extracellular matrix | GO:0031012 | 2,66E-06 | MFAP5, TNC, IGFBP7, NPNT, MMP13, LOX, TGFB2, FLRT3, TGFB1, NID1 |
B. GO Molecular functions | |||
Type II transforming growth factor beta receptor binding | GO:0005114 | 2,73E-04 | TGFB2, TGFB1 |
Fibronectin binding | GO:0001968 | 2,16E-03 | MMP13, IGFBP5 |
Lipoprotein particle receptor binding | GO:0070325 | 2,16E-03 | MMP13, DKK1 |
Insulin-like growth factor binding | GO:0005520 | 3,74E-03 | IGFBP7, IGFBP5 |
Cytokine receptor binding | GO:0005126 | 6,89E-03 | CXCL14, TNFSF15, TGFB2, TGFB1 |
C. GO Biological processes (excerpt) | |||
Extracellular matrix assembly | GO:0085029 | 4,84E-04 | LOX, TGFB1 |
Tissue morphogenesis | GO:0048729 | 6,67E-04 | TNC, TGFB2, TGFB1, PRICKLE1, DKK1, IGFBP5, DICER1 |
Regulation of apoptotic process | GO:0042981 | 9,83E-04 | AQP1, MLLT11, DEPTOR, TAF9B, ANGPT1, TP53INP1, TGFB2, TGFB1, MAPK8IP1, DICER1, HIPK3, SFN |
Extracellular matrix organization | GO:0030198 | 1,43E-03 | LOX, TGFB2, TGFB1, NID1 |
Response to steroid hormone stimulus | GO:0048545 | 5,18E-03 | AQP1, MMP13, LOX, TGFB2, TGFB1 |
Cell adhesion | GO:0007155 | 6,37E-03 | TNC, IGFBP7, NPNT, ANGPT1, GPR56, TGFB2, FLRT3, TGFB1, NID1 |
Regulation of cell migration | GO:0030334 | 7,78E-03 | PTGER4, ANGPT1, TGFB2, TGFB1, IGFBP5 |