MDT recommendation | Accuracy of prediction by | ||||||||
---|---|---|---|---|---|---|---|---|---|
Modality | Recommended | Best ML modela | ESMO Guidelines | NCCN Guidelines | |||||
Strategy | N (%) | Sens/Spec | LR+ | Sens/Spec | LR+ | Pb | Sens/Spec | LR+ | Pb |
Chemotherapy | |||||||||
Aggressive | 582 (60) | 0.93/0.89 | 8.8 | 0.55 c /0.78 c | 2.5 | <0.01 | 0.97/0.12c | 1.1 | <0.01 |
Conservative | 342 (35) | 0.86/0.95 | 16.7 | 0.60 c /0.82 c | 3.3 | <0.01 | 0.82/0.71c | 2.9 | <0.01 |
Endocrine | |||||||||
Aggressive | 916 (91) | 0.98/0.85 | 6.5 | 0.98/0.81 | 5.2 | 0.68 | 0.97/0.75 | 3.9 | 0.25 |
Conservative | 794 (79) | 0.97/0.65 | 2.8 | 0.99/0.36c | 1.5 | 0.30 | 0.96/0.50 | 1.9 | 0.37 |
Trastuzumab | |||||||||
Aggressive | 93 (20) | 0.98/0.99 | 77.9 | 0.97/0.97 | 33.3 | 0.60 | 0.97/0.98 | 45.2 | 0.73 |
Conservative | 86 (19) | 0.95/0.99 | 122.9 | 0.97/0.96 | 24.0 | 0.24 | 0.92/0.98 | 37.7 | 0.28 |