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Table 1 Baseline characteristics of early breast cancer cases discussed at the index MDT

From: Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach

Patient characteristics

Group

N

(%)

Demographics

Age group (years)

<45

141

(13)

  

45-55

242

(23)

  

56-69

393

(37)

  

≥70

266

(25)

Surgery type

Primary tumour

WLE or partial mastectomy

608

(57)

  

Total mastectomy

452

(42)

 

Lymph node

Sentinel node biopsy only

703

(66)

  

Axillary lymph node dissection

255

(24)

Nodal status

Sentinel lymph node

Involved

269

(25)

  

Not involved

590

(55)

 

Axillary lymph nodes involved

No

625

(59)

  

1-3

240

(23)

  

≥4

108

(11)

 

Extranodal spread

Present

140

(13)

Histopathology

Cell type

Invasive ductal carcinoma

818

(77)

  

Invasive lobular carcinoma

135

(13)

  

Tubular carcinoma

27

(3)

  

Mucinous carcinoma

12

(1)

  

Medullary carcinoma

8

(0.8)

  

Mixed type

8

(0.8)

  

Basal type

7

(0.7)

  

Metaplastic carcinoma

7

(0.7)

  

Other malignant tumour

42

(4)

 

Multifocal

Multifocal

83

(9)

  

Satellite lesions

66

(6)

 

Primary tumour size (cm)

≤0.5 (T1a)

42

(4)

  

0.6-1.0 (T1b)

149

(14)

  

1.1-2.0 (T1c)

423

(40)

  

2.1-5.0 (T2)

347

(33)

  

>5.0 (T3)

79

(7)

 

Histological grade

Grade 1

172

(12)

  

Grade 2

445

(42)

  

Grade 3

418

(39)

 

Lymphovascular invasion

Present

356

(33)

  

Absent

308

(29)

 

Perineural invasion

Present

40

(4)

  

Absent

111

(10)

 

Oestrogen receptor (ER) status

Positive

927

(87)

  

Negative

135

(13)

 

Progesterone receptor (PR) status

Positive

843

(79)

  

Negative

210

(20)

 

HER2 statusa

Positive

128

(12)

  

Negative

654

(61)

 

Basal Type

Yes

31

(3)

 

Cytokeratin 5/6

Positive

59

(6)

 

Ki-67 (%)

<5%

94

(9)

  

5-9%

130

(12)

  

10-29%

231

(22)

  

≥30%

153

(14)

Associated lesions

Second primary

Present

31

(3)

 

Ductal carcinoma in situ

High Grade

335

(32)

  

Intermediate Grade

196

(18)

  

Low grade

43

(4)

  

Extensive

346

(33)

  

Focal

318

(30)

 

Lobular carcinoma in situ

Focal

89

(8)

  

Extensive

60

(6)

 

Other benign lesion(s)

Present

95

(9)

  1. WLE Wide local excision
  2. NB: aHER2 status as determined by in situ hybridisation