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Table 1 Baseline characteristics of early breast cancer cases discussed at the index MDT

From: Computational prediction of multidisciplinary team decision-making for adjuvant breast cancer drug therapies: a machine learning approach

Patient characteristics Group N (%)
Demographics Age group (years) <45 141 (13)
   45-55 242 (23)
   56-69 393 (37)
   ≥70 266 (25)
Surgery type Primary tumour WLE or partial mastectomy 608 (57)
   Total mastectomy 452 (42)
  Lymph node Sentinel node biopsy only 703 (66)
   Axillary lymph node dissection 255 (24)
Nodal status Sentinel lymph node Involved 269 (25)
   Not involved 590 (55)
  Axillary lymph nodes involved No 625 (59)
   1-3 240 (23)
   ≥4 108 (11)
  Extranodal spread Present 140 (13)
Histopathology Cell type Invasive ductal carcinoma 818 (77)
   Invasive lobular carcinoma 135 (13)
   Tubular carcinoma 27 (3)
   Mucinous carcinoma 12 (1)
   Medullary carcinoma 8 (0.8)
   Mixed type 8 (0.8)
   Basal type 7 (0.7)
   Metaplastic carcinoma 7 (0.7)
   Other malignant tumour 42 (4)
  Multifocal Multifocal 83 (9)
   Satellite lesions 66 (6)
  Primary tumour size (cm) ≤0.5 (T1a) 42 (4)
   0.6-1.0 (T1b) 149 (14)
   1.1-2.0 (T1c) 423 (40)
   2.1-5.0 (T2) 347 (33)
   >5.0 (T3) 79 (7)
  Histological grade Grade 1 172 (12)
   Grade 2 445 (42)
   Grade 3 418 (39)
  Lymphovascular invasion Present 356 (33)
   Absent 308 (29)
  Perineural invasion Present 40 (4)
   Absent 111 (10)
  Oestrogen receptor (ER) status Positive 927 (87)
   Negative 135 (13)
  Progesterone receptor (PR) status Positive 843 (79)
   Negative 210 (20)
  HER2 statusa Positive 128 (12)
   Negative 654 (61)
  Basal Type Yes 31 (3)
  Cytokeratin 5/6 Positive 59 (6)
  Ki-67 (%) <5% 94 (9)
   5-9% 130 (12)
   10-29% 231 (22)
   ≥30% 153 (14)
Associated lesions Second primary Present 31 (3)
  Ductal carcinoma in situ High Grade 335 (32)
   Intermediate Grade 196 (18)
   Low grade 43 (4)
   Extensive 346 (33)
   Focal 318 (30)
  Lobular carcinoma in situ Focal 89 (8)
   Extensive 60 (6)
  Other benign lesion(s) Present 95 (9)
  1. WLE Wide local excision
  2. NB: aHER2 status as determined by in situ hybridisation