Table 1 Clinical and Pathological features of ovarian cancer patients according to deleterious BRCA1/2 mutations
From: Germline mutations in BRCA1 and BRCA2 in epithelial ovarian cancer patients in Brazil
BRCA 1/2 mut | BRCA1/2 wt | |
|---|---|---|
n = 19 | n = 81 | |
Age at diagnosis, median (range), years | 54 (39–63) | 55 (33–81) |
Time between diagnosis and inclusion (months) | 23.33 ± 14.53 | 19.83 ± 13.52 |
Histology, n (%) | ||
Serous | 18 (94.7) | 66 (81.5) |
Non-serous | 1 (5.3) | 15 (18.5) |
Clinical Stage, n (%) | ||
I/II | 0 (0) | 21 (25.9) |
III/IV | 19 (100) | 59 (72.8) |
Missing | 0 (0) | 1 (1.2) |
Region of origin, n (%) | ||
Southeast | 9 (47.4) | 48 (59.3) |
Northeast | 7 (36.8) | 21 (25.9) |
South | 2 (10.5) | 8 (9.9) |
North | 1 (5.3) | 1 (1.2) |
Abroad | 0 (0) | 2 (2.4) |
Missing | 0 (0) | 1 (1.2) |
Ancestry until 3rd degree, n (%) | ||
Brazilian only | 7 (36.8) | 31 (38.3) |
European only | 2 (10.5) | 12 (14.8) |
Japanese only | 1 (5.3) | 4 (4.9) |
Asian only | 0 (0) | 1 (1.2) |
Brazilian and European | 5 (26.3) | 16 (19.8) |
Brazilian and Indigenous | 2 (10.5) | 1 (1.2) |
Indigenous and European | 0 (0) | 1 (1.2) |
Indigenous and Brazilian and European | 2 (10.5) | 1 (1.2) |
Brazilian and African | 0 (0) | 2 (2.5) |
Brazilian and African and European | 0 (0) | 1 (1.2) |
Brazilian and Japanese | 0 (0) | 2 (2.5) |
Unknown | 0 (0) | 8 (9.9) |
Missing | 0 (0) | 1 (1.2) |
Family history for breast and/or ovarian cancer | ||
Positive (first and/or second-degree relatives) | 11 (57.9) | 20 (24.7) |
Negative | 5 (26.3) | 32 (39.5) |
Not Completely Known/Unknown | 3(15.8) | 29 (35.8) |