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Table 1 Patient Demographics and Clinical Characteristics

From: Tumor characteristics and prognosis in familial breast cancer

  BRCA-positive BRCA-wild type Sporadic p-value
Number of patientsa 33   66   1826   
  N % N % N %  
Age at diagnosis        <0.0001
  ≤ 35 14 43 11 16 102 6  
 36–45 10 30 33 50 421 23  
 46–55 5 15 11 17 547 30  
  ≥ 56 4 12 11 17 756 41  
Tumor size N = 24 N = 56 N = 1560 0.79
  < =2 cm 10 42 31 55 790 51  
  > 2 cm, <=5 cm 12 50 20 36 652 42  
  > 5 2 8 5 9 118 7  
Nodal status N = 28 N = 59 N = 1593 0.46
 Node negative 13 46 34 58 793 50  
 Node positive 15 54 25 42 800 50  
Tumor grade N = 20 N = 48 N = 1435 0.07
1 1 5 6 13 82 6  
 2 4 20 14 29 574 40  
 3 15 75 28 58 779 54  
ER status N = 26 N = 55 N = 1545 <0.0001
 Positive 14 54 37 67 1238 80  
 Negative 12 46 18 33 307 20  
PgR status N = 26 N = 54 N = 1531 0.04
 Positive 14 54 37 68 1136 74  
 Negative 12 46 17 32 395 26  
Ki67 status N = 21 N = 29 N = 1079 0.87
 Low 6 29 10 35 327 30  
 High 15 71 19 65 752 70  
cerb-B2 status N = 22 N = 33 N = 1069 0.01
 Negative 20 91 21 64 884 83  
 Positive 2 9 12 36 185 17  
  1. ER estrogen receptor, PgR progesterone receptor
  2. aThe 21 patients carrying variants of unknown significance were excluded from the analysis. Comparisons were made by Chi-square test/asymptomatic Fisher’s exact test