Tumor characteristics and prognosis in familial breast cancer

BMC Cancer

Table 1 Patient Demographics and Clinical Characteristics

	BRCA-positive		BRCA-wild type		Sporadic		p-value
Number of patients^a	33		66		1826
	N	%	N	%	N	%
Age at diagnosis							<0.0001
≤ 35	14	43	11	16	102	6
36–45	10	30	33	50	421	23
46–55	5	15	11	17	547	30
≥ 56	4	12	11	17	756	41
Tumor size	N = 24		N = 56		N = 1560		0.79
< =2 cm	10	42	31	55	790	51
> 2 cm, <=5 cm	12	50	20	36	652	42
> 5	2	8	5	9	118	7
Nodal status	N = 28		N = 59		N = 1593		0.46
Node negative	13	46	34	58	793	50
Node positive	15	54	25	42	800	50
Tumor grade	N = 20		N = 48		N = 1435		0.07
1	1	5	6	13	82	6
2	4	20	14	29	574	40
3	15	75	28	58	779	54
ER status	N = 26		N = 55		N = 1545		<0.0001
Positive	14	54	37	67	1238	80
Negative	12	46	18	33	307	20
PgR status	N = 26		N = 54		N = 1531		0.04
Positive	14	54	37	68	1136	74
Negative	12	46	17	32	395	26
Ki67 status	N = 21		N = 29		N = 1079		0.87
Low	6	29	10	35	327	30
High	15	71	19	65	752	70
cerb-B2 status	N = 22		N = 33		N = 1069		0.01
Negative	20	91	21	64	884	83
Positive	2	9	12	36	185	17

ER estrogen receptor, PgR progesterone receptor
^aThe 21 patients carrying variants of unknown significance were excluded from the analysis. Comparisons were made by Chi-square test/asymptomatic Fisher’s exact test

ISSN: 1471-2407