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Table 1 Valproic acid dose titration

From: Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial

Days Morning dose (mg) Afternoon dose (mg) Evening dose (mg)
−14 and −13 0 0 500
−12 and −11 300 0 500
−10 and −9 500 0 500
−8 and −7 500 300 500
−6 and −5 500 500 500
−4 and −3 500 500 500
−2 and −1 500 500 500
  1. The interval between each dose will be 12 h from the −14 day to −9 day and it will be 8 h from −8 day