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Table 1 Valproic acid dose titration

From: Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial

Days

Morning dose (mg)

Afternoon dose (mg)

Evening dose (mg)

−14 and −13

0

0

500

−12 and −11

300

0

500

−10 and −9

500

0

500

−8 and −7

500

300

500

−6 and −5

500

500

500

−4 and −3

500

500

500

−2 and −1

500

500

500

  1. The interval between each dose will be 12 h from the −14 day to −9 day and it will be 8 h from −8 day
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BMC Cancer

ISSN: 1471-2407

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