Table 1 Cancer stem cell structure, associated unique genetic events and chemotherapy curability
From: Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis
Metastatic malignancy | Cancer stem cell model | Associated unique genetic event | Chemotherapy curability |
|---|---|---|---|
Common epithelial cancers | Hierarchical | None | - |
Gestational trophoblast tumours | Non-hierarchical | Nuclear fusion | +++ |
Germ cell tumours | Non-hierarchical | Meiosis | +++ |
Childhood malignancies | Non-hierarchical | Gastrulation | + |
B and T cell malignancies | Â | Â | Â |
Acute undifferentiated leukemia | Hierarchical | None | - |
Acute lymphocytic leukemia | Non-hierarchical | VDJ | +++ |
ALK + ve T Cell lymphoma | Non-hierarchical | VDJ | ++ |
Mantle cell lymphoma | Non-hierarchical | None | - |
Diffuse large B Cell lymphoma | Non-hierarchical | SHM | ++ |
Burkitt’s lymphoma | Non-hierarchical | SHM | ++ |
Hodgkin lymphoma | Non-hierarchical | SHM | ++ |
CLL | Non-hierarchical | None | - |
Myeloma | Non-hierarchical | None | - |
Mature T cell malignancies | Non-hierarchical | None | - |