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Table 2 Univariate analysis for OS in non-oligometastatic patients

From: Might radiation therapy in addition to chemotherapy improve overall survival of patients with non-oligometastatic Stage IV non-small cell lung cancer?: Secondary analysis of two prospective studies

Variable Pre-PSM Cohort Post-PSM Cohort
No 1-yr 2-yr 3-yr Statistic value No 1-yr 2-yr 3-yr Statistic value
Gender           
 Male 125 41.6 12.8 4.3 χ2 = 1.804 85 36.5 11.8 3.5 χ2 = 2.153
 Female 58 56.9 12.4 7.8 P = 0.179 33 7.6 12.1 6.1 P = 0.142
Age (years)           
 <60 100 48.0 11.0 3.7 χ2 = 0.009 58 44.8 12.1 4.0 χ2 = 0.295
 ≥60 83 44.6 14.9 7.4 P = 0.926 60 40.0 11.7 6.7 P = 0.587
Tumor histology           
 Adenocarcinoma 108 52.8 14.1 6.4 χ2 = 2.777 65 41.5 12.3 6.6 χ2 = 0.443
 Squamous carcinoma 59 37.3 10.2 5.1 P = 0.250 44 40.9 9.1 4.5 P = 0.801
 others 16 37.5 12.5 0.0   9 55.6 11.1 0.0  
Pre-treatment KPS           
 70-80 110 49.1 12.0 5.6 χ2 = 0.255 64 43.8 7.8 4.7 χ2 = 0.001
 >80 73 42.5 13.7 4.3 P = 0.614 54 40.7 16.7 5.2 P = 0.976
T stage           
 T1-2 69 50.7 11.9 5.0 χ2 = 0.018 41 39.0 9.8 4.9 χ2 = 0.862
 T3-4 114 43.9 13.2 4.8 P = 0.914 77 44.2 13.0 5.4 P = 0.353
N stage           
 N0-1 25 68.0 21.3 11.3 χ2 = 3.696 17 64.7 17.6 17.6 χ2 = 3.242
 N2-3 158 43.0 11.4 4.5 P = 0.055 101 38.6 10.9 3.6 P = 0.072
Gross tumor volume, cm3           
 <146 90 59.2 17.5 6.7 χ2 = 7.319 46 50.0 10.9 4.3 χ2 = 0.618
 ≥146 93 37.6 9.7 4.2 P = 0.007 72 37.5 12.5 6.2 P = 0.432
Post-treatment KPS           
 Increased or stable 151 52.3 14.8 5.9 χ2 = 15.807 95 47.4 13.7 5.7 χ2 = 6.011
 Decreased 32 18.8 3.1 3.1 P = 0.000 23 21.7 4.3 4.3 P = 0.014
Radiation dose, Gy           
 ≥63 90 51.1 21.1 11.2 χ2 = 8.257 59 47.5 20.3 10.8 χ2 = 7.013
 <63 93 41.9 6.6 0.0 P = 0.004 59 37.3 3.4 0 P = 0.008
Chemotherapy cycles           
 <4 95 37.9 8.7 2.5 χ2 = 5.334 60 31.7 6.7 4.4 χ2 = 3.775
 ≥4 88 55.7 1.7 8.3 P = 0.021 58 53.4 17.2 6.5 P = 0.052
Metastasis status           
 Single organ 78 46.2 16.7 8.3 χ2 = 1.622 50 46.0 18.0 8.0 χ2 = 2.739
 2 to 3 organs 105 46.7 9.7 2.9 P = 0.203 68 39.7 7.4 3.7 P = 0.098
Response to chemotherapy           
 No 51 25.5 7.8 3.9 χ2 = 10.428 32 21.9 6.2 3.1 χ2 = 6.230
 Yes 132 54.5 14.6 5.9 P = 0.001 86 50.0 14.0 6.1 P = 0.013