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Table 2 Univariate analysis for OS in non-oligometastatic patients

From: Might radiation therapy in addition to chemotherapy improve overall survival of patients with non-oligometastatic Stage IV non-small cell lung cancer?: Secondary analysis of two prospective studies

Variable

Pre-PSM Cohort

Post-PSM Cohort

No

1-yr

2-yr

3-yr

Statistic value

No

1-yr

2-yr

3-yr

Statistic value

Gender

          

 Male

125

41.6

12.8

4.3

χ2 = 1.804

85

36.5

11.8

3.5

χ2 = 2.153

 Female

58

56.9

12.4

7.8

P = 0.179

33

7.6

12.1

6.1

P = 0.142

Age (years)

          

 <60

100

48.0

11.0

3.7

χ2 = 0.009

58

44.8

12.1

4.0

χ2 = 0.295

 ≥60

83

44.6

14.9

7.4

P = 0.926

60

40.0

11.7

6.7

P = 0.587

Tumor histology

          

 Adenocarcinoma

108

52.8

14.1

6.4

χ2 = 2.777

65

41.5

12.3

6.6

χ2 = 0.443

 Squamous carcinoma

59

37.3

10.2

5.1

P = 0.250

44

40.9

9.1

4.5

P = 0.801

 others

16

37.5

12.5

0.0

 

9

55.6

11.1

0.0

 

Pre-treatment KPS

          

 70-80

110

49.1

12.0

5.6

χ2 = 0.255

64

43.8

7.8

4.7

χ2 = 0.001

 >80

73

42.5

13.7

4.3

P = 0.614

54

40.7

16.7

5.2

P = 0.976

T stage

          

 T1-2

69

50.7

11.9

5.0

χ2 = 0.018

41

39.0

9.8

4.9

χ2 = 0.862

 T3-4

114

43.9

13.2

4.8

P = 0.914

77

44.2

13.0

5.4

P = 0.353

N stage

          

 N0-1

25

68.0

21.3

11.3

χ2 = 3.696

17

64.7

17.6

17.6

χ2 = 3.242

 N2-3

158

43.0

11.4

4.5

P = 0.055

101

38.6

10.9

3.6

P = 0.072

Gross tumor volume, cm3

          

 <146

90

59.2

17.5

6.7

χ2 = 7.319

46

50.0

10.9

4.3

χ2 = 0.618

 ≥146

93

37.6

9.7

4.2

P = 0.007

72

37.5

12.5

6.2

P = 0.432

Post-treatment KPS

          

 Increased or stable

151

52.3

14.8

5.9

χ2 = 15.807

95

47.4

13.7

5.7

χ2 = 6.011

 Decreased

32

18.8

3.1

3.1

P = 0.000

23

21.7

4.3

4.3

P = 0.014

Radiation dose, Gy

          

 ≥63

90

51.1

21.1

11.2

χ2 = 8.257

59

47.5

20.3

10.8

χ2 = 7.013

 <63

93

41.9

6.6

0.0

P = 0.004

59

37.3

3.4

0

P = 0.008

Chemotherapy cycles

          

 <4

95

37.9

8.7

2.5

χ2 = 5.334

60

31.7

6.7

4.4

χ2 = 3.775

 ≥4

88

55.7

1.7

8.3

P = 0.021

58

53.4

17.2

6.5

P = 0.052

Metastasis status

          

 Single organ

78

46.2

16.7

8.3

χ2 = 1.622

50

46.0

18.0

8.0

χ2 = 2.739

 2 to 3 organs

105

46.7

9.7

2.9

P = 0.203

68

39.7

7.4

3.7

P = 0.098

Response to chemotherapy

          

 No

51

25.5

7.8

3.9

χ2 = 10.428

32

21.9

6.2

3.1

χ2 = 6.230

 Yes

132

54.5

14.6

5.9

P = 0.001

86

50.0

14.0

6.1

P = 0.013