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Table 3 Comparison of clinicopathologic features between K19-positive and K19- negative HCC (n = 136 cases)

From: Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis

Features K19-positive group [n = 12 (8.8%)] K19-negative group [n = 124 (91.2%)] P value
Age (years, mean ± SD) 60.1 ± 16.4 69.7 ± 9.32 0.002
Gender (male:female) (male%) 5:7 (41.7) 98:26 (79.0) 0.004
Infection
 HBV (%) 4 (33.3) 29 (23.4) 0.443
 HCV (%) 4 (33.3) 58 (46.8) 0.372
 Non-HBV, non- HCV (%) 4 (33.3) 39 (31.5) 0.894
Cirrhosis (%) 3 (25.0) 40 (32.3) 0.606
Tumour size (mm, mean ± SD) 42.2 ± 33.3 37.0 ± 24.8 0.505
Multiple tumours (%) 2 (16.7) 14 (11.3) 0.581
TNM stage    <0.001
 I-II (%) 4 (33.3) 63 (50.8)  
 III-IV (%) 8 (66.6) 61 (49.2)  
Differentiation    <0.001
 Well (%) 0 (0) 33 (26.6)  
 Moderate (%) 7 (58.3) 84 (67.7)  
 Poor (%) 5 (41.7) 7 (5.6)  
Major vascular invasion (%) 3 (25.0) 3 (2.4) <0.001
Microvascular invasion (%) 10 (83.3) 68 (54.8) 0.063
Tumour-capsule formation (%) 5 (41.7) 98 (79.0) 0.004
Fibrous stroma (%) 5 (41.7) 41 (33.1) 0.575
Necrosis (%) 9 (75.0) 34 (27.4) <0.001
Recurrence (%) 5 (41.7) 54 (43.5) 0.977
Early recurrencea (%) 5 (41.7) 16 (12.9) 0.005
Extrahepatic recurrence (%) 5 (41.7) 13 (10.5) 0.002
Lung (%) 4 (33.3) 9 (7.3) 0.003
Bone (%) 1 (8.3) 2 (1.6) 0.130
Lymph nodes (%) 1 (8.3) 3 (2.4) 0.247
Adrenal gland (%) 0(0) 1 (0.8) 0.755
  1. aEarly recurrence within 6 months after surgery