Table 3 Comparison of clinicopathologic features between K19-positive and K19- negative HCC (n = 136 cases)
Features | K19-positive group [n = 12 (8.8%)] | K19-negative group [n = 124 (91.2%)] | P value |
|---|---|---|---|
Age (years, mean ± SD) | 60.1 ± 16.4 | 69.7 ± 9.32 | 0.002 |
Gender (male:female) (male%) | 5:7 (41.7) | 98:26 (79.0) | 0.004 |
Infection | |||
 HBV (%) | 4 (33.3) | 29 (23.4) | 0.443 |
 HCV (%) | 4 (33.3) | 58 (46.8) | 0.372 |
 Non-HBV, non- HCV (%) | 4 (33.3) | 39 (31.5) | 0.894 |
Cirrhosis (%) | 3 (25.0) | 40 (32.3) | 0.606 |
Tumour size (mm, mean ± SD) | 42.2 ± 33.3 | 37.0 ± 24.8 | 0.505 |
Multiple tumours (%) | 2 (16.7) | 14 (11.3) | 0.581 |
TNM stage | Â | Â | <0.001 |
 I-II (%) | 4 (33.3) | 63 (50.8) |  |
 III-IV (%) | 8 (66.6) | 61 (49.2) |  |
Differentiation | Â | Â | <0.001 |
 Well (%) | 0 (0) | 33 (26.6) |  |
 Moderate (%) | 7 (58.3) | 84 (67.7) |  |
 Poor (%) | 5 (41.7) | 7 (5.6) |  |
Major vascular invasion (%) | 3 (25.0) | 3 (2.4) | <0.001 |
Microvascular invasion (%) | 10 (83.3) | 68 (54.8) | 0.063 |
Tumour-capsule formation (%) | 5 (41.7) | 98 (79.0) | 0.004 |
Fibrous stroma (%) | 5 (41.7) | 41 (33.1) | 0.575 |
Necrosis (%) | 9 (75.0) | 34 (27.4) | <0.001 |
Recurrence (%) | 5 (41.7) | 54 (43.5) | 0.977 |
Early recurrencea (%) | 5 (41.7) | 16 (12.9) | 0.005 |
Extrahepatic recurrence (%) | 5 (41.7) | 13 (10.5) | 0.002 |
Lung (%) | 4 (33.3) | 9 (7.3) | 0.003 |
Bone (%) | 1 (8.3) | 2 (1.6) | 0.130 |
Lymph nodes (%) | 1 (8.3) | 3 (2.4) | 0.247 |
Adrenal gland (%) | 0(0) | 1 (0.8) | 0.755 |