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Fig. 1 | BMC Cancer

Fig. 1

From: Comparing conVEntional RadioTherapy with stereotactIC body radiotherapy in patients with spinAL metastases: study protocol for an randomized controlled trial following the cohort multiple randomized controlled trial design

Fig. 1

Study design VERTICAL study A large observational cohort of patients with bone metastases is recruited and their outcomes regularly measured (dark blue box). Patients within the PRESENT cohort who meet the VERTICAL inclusion criteria are identified as a sub cohort of eligible patients (light blue box). Randomly selected patients (orange box) are offered the SBRT intervention. The outcomes of these randomly selected patients (i.e. the intervention arm) are then compared with the outcomes of eligible patients not randomly selected who receive standard of care (i.e. the control arm, brown boxes)

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