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Table 3 Correlative biomarkers in subjects treated with mTMZ.  Tumor blood flow was measured by arterial spin labeling (ASL) MRI while CSF levels of aMMP-2, aMMP-9 and sIL-2α were measured by ELISA

From: Phase I study of low-dose metronomic temozolomide for recurrent malignant gliomas

No Number of ASL scans Tumor blood flow aMMP-2 aMMP-9 sIL-2Rα
   Blood flow average (cc/g · min, across all time points) Blood flow ratio (Baseline) Blood flow ratio (Mean, across all time points) Baseline (ng/mL) Mean (ng/mL) Baseline (pg/mL) Mean (pg/mL) Baseline (pg/mL) Mean (pg/mL)
1 2 11.7 0.98 1.08       
2 2 42.4 0.99 0.99       
3 2 26.0 1.35 1.31       
4 2 21.8 0.80 0.64 13.7 7.0 13.2 11.0 0 0
5 5 23.4 0.70 0.88 13.9 13.4 5.7 7.2 11.3 9.7
6 18 42.2 0.92 0.90 16.7 16.7 6.6 7.3 19.5 18.1
7 2 46.3 0.68 0.88 9.7 12.5 5.9 9.2 0 3.8
8 9 17.1 0.59 0.58 13.9 15.1 11.9 8.4 18.1 21.9
9 7 13.8 0.91 0.58 14.0 11.2 4.0 3.8 0 2.5