Fig. 1

VEGF-A expression in PPARgamma KO mice and human lung tumors. a, Hematoxylin eosin staining and immunofluorescent staining of the lung of wild type C57BL/6 and PPARgamma knock-out (KO) mice show a significantly increased level of mVEGF-A in KO lung tissues. Scale bars, 200 μm and 50 μm. Intensity data are representation of three independent experiments as mean ± SEM. b, Resected human lung AC and SCC revealed significant PPARgamma decrease and VEGF-A expression increase. Data are presented as mean ± SEM. One-way ANOVA, post hoc Bonferroni; n = 11 and n = 12 per groups. P < 0.05 was considered as significant, * p < 0.05, ** p < 0.01, *** p < 0.001