Subgroups | N | No. samples | Heterogeneity (I2, p) | Model | HR with 95 % CI | P value | Conclusion | ||
---|---|---|---|---|---|---|---|---|---|
Total | PE | NE | |||||||
Subgroups stratified by statistical analysis | |||||||||
Multivariate analysis | 4 | 533 | 283 | 250 | I2 = 26.0 %, p = 0.255 | Fixed | 2.071 (1.557–2.753) | <0.001 | Significant |
Univariate analysis | 2 | 180 | 98 | 82 | I2 = 0.0 %, p = 0.592 | Fixed | 1.915 (1.114–3.292) | 0.019 | Significant |
Subgroups stratified by cut-off values | |||||||||
10 % staining | 3 | 325 | 174 | 151 | I2 = 0.0 %, p = 0.731 | Fixed | 2.577 (1.788–3.714) | <0.001 | Significant |
Non-10 % staining | 3 | 388 | 207 | 181 | I2 = 0.0 %, p = 0.694 | Fixed | 1.644 (1.160–2.328) | 0.005 | Significant |
Subgroups stratified by follow-up periods | |||||||||
≥ 5-year OS | 5 | 565 | 287 | 278 | I2 = 9.2 %, p = 0.354 | Fixed | 2.037 (1.542–2.689) | <0.001 | Significant |
< 5-year OS | 1 | 148 | 94 | 54 | –––– | –––– | 2.033 (1.117–3.701) | 0.020 | Significant |
Subgroups stratified by positive-staining sites | |||||||||
Cytoplasm | 4 | 473 | 268 | 205 | I2 = 0.0 %, p = 0.785 | Fixed | 2.416 (1.769–3.301) | <0.001 | Significant |
Nucleus or membrane | Given up because of the scarcity of available data |