Clinicopathological and prognostic significance of mTOR and phosphorylated mTOR expression in patients with esophageal squamous cell carcinoma: a systematic review and meta-analysis

Table 4 Meta-analysis of prognostic roles of mTOR/p-mTOR expression in patients with ESCC

Endpoint event	N	No. samples			Heterogeneity (I², p)	Model	HR with 95 % CI	P value	Publication bias		Conclusion
Endpoint event	N	Total	PE	NE	Heterogeneity (I², p)	Model	HR with 95 % CI	P value	Begg (p)	Egger (p)	Conclusion
Overall survival	6	713	381	332	I² = 0.0 %, p = 0.493	Fixed	2.036 (1.582–2.620)	<0.001	1.0	0.663	Significant
Disease-free survival	3	330	197	133	I² = 0.0 %, p = 0.970	Fixed	2.390 (1.637–3.490)	<0.001	1.0	0.941	Significant
Cancer-specific survival	2	308	145	163	I² = 0.0 %, p = 0.853	Fixed	1.620 (1.179–2.229)	0.003	1.0	NI	Significant

CI confidence interval, ESCC esophageal squamous cell carcinoma, HR hazard ratio, mTOR Mammalian Target of Rapamycin, N reference count, NE negative expression, NI no information, PE positive expression, p-mTOR Phosphorylated Mammalian Target of Rapamycin

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