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Table 3 Design quality of included trials

From: Thoracic perfusion of recombinant human endostatin (Endostar) combined with chemotherapeutic agents versus chemotherapeutic agents alone for treating malignant pleural effusions: a systematic evaluation and meta-analysis

Studies Region Sequence generation Allocation concealment Blind Outcome data Selective outcome reporting Other sources of bias ITT Risk of bias
Liu W 2010 [15] Single center Random number table (SPSS) Clear Clear Yes No Clear No Unclear risk of bias
Mao L 2011 [16] Single center Random number table (SAS) Unclear Unclear Yes No Clear Yes Unclear risk of bias
Li G 2011 [17] Single center Random number table (SAS) sufficient Unclear Yes No Clear Yes Low risk of bias
Ma E 2012 [18] Single center Random number table (SPSS) Unclear Unclear Yes No Clear No Unclear risk of bias
Yao Q 2012 [19] Single center Random number table (SPSS) Unclear Unclear Yes No Clear No Unclear risk of bias
Zheng Q 2013 [20] Single center Random number table (SAS) sufficient Unclear Yes No Clear Yes Low risk of bias
Kang Y 2013 [21] Single center Random number table (SAS) Unclear Unclear Yes N0 Clear Yes Unclear risk of bias
Wen J 2014 [22] Single center unclear Unclear Unclear Yes N0 Clear Yes Unclear risk of bias
Yue G 2014 [23] Single center Random number table (SAS) Unclear Unclear Yes No Clear Yes Unclear risk of bias
Tu J 2014 [24] Single center Random number table (SPSS) Insufficient Unclear Yes No Unclear Yes Low risk of bias
Xu J 2014 [25] Single center Random number table (SPSS) Unclear Clear Yes No Unclear No Unclear risk of bias
Wen X 2015 [26] Single center Random number table (SPSS) Unclear Unclear Yes No Clear No Unclear risk of bias
Hu X 2015 [27] Single center unclear Insufficient Unclear Yes No Clear No Low risk of bias
  1. SAS SAS software, SPSS SPSS software, ITT intention-to-treat