Thoracic perfusion of recombinant human endostatin (Endostar) combined with chemotherapeutic agents versus chemotherapeutic agents alone for treating malignant pleural effusions: a systematic evaluation and meta-analysis

Table 3 Design quality of included trials

Studies	Region	Sequence generation	Allocation concealment	Blind	Outcome data	Selective outcome reporting	Other sources of bias	ITT	Risk of bias
Liu W 2010 [15]	Single center	Random number table (SPSS)	Clear	Clear	Yes	No	Clear	No	Unclear risk of bias
Mao L 2011 [16]	Single center	Random number table (SAS)	Unclear	Unclear	Yes	No	Clear	Yes	Unclear risk of bias
Li G 2011 [17]	Single center	Random number table (SAS)	sufficient	Unclear	Yes	No	Clear	Yes	Low risk of bias
Ma E 2012 [18]	Single center	Random number table (SPSS)	Unclear	Unclear	Yes	No	Clear	No	Unclear risk of bias
Yao Q 2012 [19]	Single center	Random number table (SPSS)	Unclear	Unclear	Yes	No	Clear	No	Unclear risk of bias
Zheng Q 2013 [20]	Single center	Random number table (SAS)	sufficient	Unclear	Yes	No	Clear	Yes	Low risk of bias
Kang Y 2013 [21]	Single center	Random number table (SAS)	Unclear	Unclear	Yes	N0	Clear	Yes	Unclear risk of bias
Wen J 2014 [22]	Single center	unclear	Unclear	Unclear	Yes	N0	Clear	Yes	Unclear risk of bias
Yue G 2014 [23]	Single center	Random number table (SAS)	Unclear	Unclear	Yes	No	Clear	Yes	Unclear risk of bias
Tu J 2014 [24]	Single center	Random number table (SPSS)	Insufficient	Unclear	Yes	No	Unclear	Yes	Low risk of bias
Xu J 2014 [25]	Single center	Random number table (SPSS)	Unclear	Clear	Yes	No	Unclear	No	Unclear risk of bias
Wen X 2015 [26]	Single center	Random number table (SPSS)	Unclear	Unclear	Yes	No	Clear	No	Unclear risk of bias
Hu X 2015 [27]	Single center	unclear	Insufficient	Unclear	Yes	No	Clear	No	Low risk of bias

ISSN: 1471-2407