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Table 2 Assessment of administration of included studies

From: Thoracic perfusion of recombinant human endostatin (Endostar) combined with chemotherapeutic agents versus chemotherapeutic agents alone for treating malignant pleural effusions: a systematic evaluation and meta-analysis

Study Trial group (N) Control group (N) Interventions Treatment cycle Termination of treatment
Endostar combined with chemotherapeutic agents Chemotherapeutic agents alone
Liu W 2010 [15] 32 32 Cisplatin 40 mg/m2, 1/week
Endostar 30 mg, 1/week
Cisplatin 40 mg/m2, 1/w 3 weeks >3 weeks, or pleural effusion disappeared
Mao L 2011 [16] 45 45 Cisplatin 40 mg/m2, 1/week
Endostar 30 mg, 2/week
Cisplatin 40 mg/m2, 1/7d 7d/cycle,
2 cycles
>4 cycles, or pleural effusion disappeared
Li G 2011 [17] 30 30 Bleomycin 60 mg, 1/week
Endostar 30 mg, 1/week
Bleomycin 60 mg, 1/w 3 weeks >3 weeks, or pleural effusion disappeared
Ma E 2012 [18] 28 28 Cisplatin 40 mg/m2, 1/week
Endostar 30 mg, 1/week
Cisplatin 40 mg/m2, 1/w 4 weeks >4 weeks, or pleural effusion disappeared
Yao Q 2012 [19] 30 30 Nedaplatin 40 mg, 1/week
Endostar 45 mg, 1/week
Nedaplatin 40 mg, 1/w 4 weeks >4 weeks, or pleural effusion disappeared
Zheng Q 2013 [20] 60 60 Cisplatin 30–40 mg, d1–3
Endostar 90 mg, d4
Cisplatin 30–40 mg d1–3 21d/cycle,
1–4 cycles
>4 cycles, or pleural effusion disappeared
Kang Y 2013 [21] 45 45 Cisplatin 40 mg, 2/week
Endostar 30 mg, 2/week
Cisplatin 40 mg, 2/w 3 weeks >3 weeks, or pleural effusion disappeared
Wen J 2014 [22] 25 29 Lobaplatin 30 mg/m2, d1
Endostar 30 mg, d1
Lobaplatin 30 mg/m2, d1 4 cycles >4 cycles, or pleural effusion disappeared
Yue G 2014 [23] 43 43 Cisplatin 60 mg, 1/week
Endostar 30 mg, 2/week
Cisplatin 60 mg, 1/w 2–3 weeks >4 weeks, or pleural effusion disappeared
Tu J [24] 45 45 Cisplatin 40 mg/m2, 2/week
Endostar 45 mg, 2/week
Cisplatin 40 mg/m2, 2/w 3 weeks >3 weeks, or pleural effusion disappeared
Xu J 2014 [25] 35 35 Nedaplatin 60 mg, 1/week
Endostar 60 mg, 1/week
Nedaplatin 60 mg, 1/w 4 weeks >4 weeks, or pleural effusion disappeared
Wen X 2015 [26] 68 36 Bleomycin 45 mg, w1
Endostar 45 mg, w2
Bleomycin 45 mg, 1/7d 7d/cycle,
2–4 cycles
>2 weeks, or pleural effusion disappeared
Hu X 2015 [27] 43 41 Cisplatin 40 mg, 2/week
Endostar 60 mg, 2/week
Cisplatin 40 mg, 2/week 2 weeks >2 weeks, or pleural effusion disappeared
  1. N numbers of patients, d day, w week