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Table 6 Multivariable logistic regression analysis of risk factors for neutropenia

From: Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Variables Grade 0–2
(N = 202)
Grade 3–4
(N = 32)
Univariate Multivariate a)
OR (95% CI) p OR (95% CI) p
Age (y)     0.99 (0.42–2.33) 0.554   
Sex F 70 (80.5%) 17 (19.5%) 2.14 (1.01–4.54) 0.048 2.24 (1.03–4.87) 0.043
M 132 (89.8%) 15 (10.2%) 1.00 1.00
Operation type Total 73 (78.5%) 20 (21.5%) 2.95 (1.36–6.37) 0.006 2.71 (1.23–5.97) 0.013
Distal 129 (91.5%) 12 (8.5%) 1.00 1.00
Creatinine clearance (mL/min) b) ≥60 170 (86.3%) 27 (13.7%) 1.00 0.975   
<60 32 (86.5%) 5 (13.5%) 0.98 (0.35–2.75)  
Albumin (g/dL) <3.5 25 (73.5%) 9 (26.5%) 2.77 (1.15–6.66) 0.023 2.61 (1.01–6.54) 0.040
≥3.5 177 (88.5%) 23 (11.5%) 1.00 1.00
BMI (kg/m2)     0.87 (0.75–1.00) 0.054   
PG-SGA category A 80 (83.3%) 16 (16.7%) 1.00 0.106   
B 122 (88.4%) 16 (11.6%) 0.44 (0.16–1.19)
PG-SGA score     0.87 (0.75–1.02) 0.080   
Weight loss (%)     1.11 (0.92–1.12) 0.728   
NRI     0.95 (0.89–1.01) 0.110   
  1. a)Covariates used in multivariate analyses included sex, operation type, and albumin; b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index