Association of nutritional status-related indices and chemotherapy-induced adverse events in gastric cancer patients

Table 6 Multivariable logistic regression analysis of risk factors for neutropenia

Variables		Grade 0–2 (N = 202)	Grade 3–4 (N = 32)	Univariate		Multivariate ^a)
Variables		Grade 0–2 (N = 202)	Grade 3–4 (N = 32)	OR (95% CI)	p	OR (95% CI)	p
Age (y)				0.99 (0.42–2.33)	0.554
Sex	F	70 (80.5%)	17 (19.5%)	2.14 (1.01–4.54)	0.048	2.24 (1.03–4.87)	0.043
Sex	M	132 (89.8%)	15 (10.2%)	1.00	0.048	1.00	0.043
Operation type	Total	73 (78.5%)	20 (21.5%)	2.95 (1.36–6.37)	0.006	2.71 (1.23–5.97)	0.013
Operation type	Distal	129 (91.5%)	12 (8.5%)	1.00	0.006	1.00	0.013
Creatinine clearance (mL/min) ^b)	≥60	170 (86.3%)	27 (13.7%)	1.00	0.975
Creatinine clearance (mL/min) ^b)	<60	32 (86.5%)	5 (13.5%)	0.98 (0.35–2.75)	0.975
Albumin (g/dL)	<3.5	25 (73.5%)	9 (26.5%)	2.77 (1.15–6.66)	0.023	2.61 (1.01–6.54)	0.040
Albumin (g/dL)	≥3.5	177 (88.5%)	23 (11.5%)	1.00	0.023	1.00	0.040
BMI (kg/m²)				0.87 (0.75–1.00)	0.054
PG-SGA category	A	80 (83.3%)	16 (16.7%)	1.00	0.106
PG-SGA category	B	122 (88.4%)	16 (11.6%)	0.44 (0.16–1.19)	0.106
PG-SGA score				0.87 (0.75–1.02)	0.080
Weight loss (%)				1.11 (0.92–1.12)	0.728
NRI				0.95 (0.89–1.01)	0.110

^a)Covariates used in multivariate analyses included sex, operation type, and albumin; ^b)Creatinine clearance was calculated using the Cockroft–Gault formula; BMI Body Mass Index, PG-SGA Patient-Generated Subjective Global Assessment, NRI Nutritional Risk Index

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